Integrating bioinformatics and experimental validation to Investigate IRF1 as a novel biomarker for nucleus pulposus cells necroptosis in intervertebral disc degeneration

Integrating bioinformatics and experimental validation to Investigate IRF1 as a novel biomarker for nucleus pulposus cells necroptosis in intervertebral disc degeneration

Abstract Intervertebral disc degeneration (IDD) is a prevalent spinal disorder and the principal cause of lower back pain (LBP). Diverse forms of programmed cell death (PCD) have been identified as the key phenotypes of the disease and have the potential to serve as new indicators for the diagnosis...

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Bibliographic Details
Main Authors: Kaisheng Zhou, Shaobo Wu, Zuolong Wu, Rui Ran, Wei Song, Hao Dong, Haihong Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
IRF1
Necroptosis
Intervertebral disc degeneration
Nucleus pulposus
Biomarker
Online Access:https://doi.org/10.1038/s41598-024-81681-8
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https://doi.org/10.1038/s41598-024-81681-8

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