Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions

Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions

IntroductionMacrophages play an important role in disease progression of pediatric cholestatic liver disease, particularly biliary atresia (BA); however, the restorative versus pathogenic role for precise macrophage subsets remains poorly defined. We aimed to distinguish the transcriptional profiles...

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Main Authors: Kyle D. Gromer, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Colin Shearn, Swati Antala, Joshua B. Wechsler, Carla M. Cuda, Cara L. Mack, Ronald J. Sokol, William J. Janssen, Richard M. Green, Harris Perlman, Deborah R. Winter, Sarah A. Taylor
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
cholestasis
obstructive cholangiopathy
pediatric liver disease
innate immunity
hepatic macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1506195/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1506195/full

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