Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions. Translocation across the intestinal barrier into the bloodstream by intestine-colonizing C. albicans cells serves as t...

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Main Authors: Jakob L Sprague, Tim B Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L Priest, Antzela Tsavou, Gianni Panagiotou, Julian R Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard Hube
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012031
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https://doi.org/10.1371/journal.ppat.1012031

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