A variant form of receptor activator of nuclear factor-κB functions as an osteoprotegerin mimic in bone and cardiac development

A variant form of receptor activator of nuclear factor-κB functions as an osteoprotegerin mimic in bone and cardiac development

Abstract Bone remodeling is tightly regulated by the RANK-RANKL-OPG axis to maintain skeletal integrity. We previously identified a RANK splicing variant, vRANK, which encodes a truncated protein that inhibits osteoclastogenesis and promotes apoptosis. This study examined the regulatory mechanisms o...

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Bibliographic Details
Main Authors: Riko Kitazawa, Ryuma Haraguchi, Sohei Kitazawa
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
RANK
Osteoclasts
Bone
Heart
Sam68
Online Access:https://doi.org/10.1038/s41598-025-13314-7
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