Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome
Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integrat...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/9353929 |
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| author | Tao Yang Huan Zhao Changbo Lu Xiaoyu Li Yingli Xie Hao Fu Hui Xu |
| author_facet | Tao Yang Huan Zhao Changbo Lu Xiaoyu Li Yingli Xie Hao Fu Hui Xu |
| author_sort | Tao Yang |
| collection | DOAJ |
| description | Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learning disability, anxiety, autistic traits, and so forth. Specifically, the morbidity of anxiety in FXS individuals remains high from childhood to adulthood. By and large, it is common that the change of brain plasticity plays a key role in the progression of disease. But for now, most studies excessively emphasized the one-sided factor on the change of synaptic plasticity participating in the generation of anxiety during the development of FXS. Here we proposed an integrated concept to acquire better recognition about the details of this process. |
| format | Article |
| id | doaj-art-94e52d5050fb49c2a7715cc864e57abf |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-94e52d5050fb49c2a7715cc864e57abf2025-02-03T01:23:20ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/93539299353929Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X SyndromeTao Yang0Huan Zhao1Changbo Lu2Xiaoyu Li3Yingli Xie4Hao Fu5Hui Xu6Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaFragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learning disability, anxiety, autistic traits, and so forth. Specifically, the morbidity of anxiety in FXS individuals remains high from childhood to adulthood. By and large, it is common that the change of brain plasticity plays a key role in the progression of disease. But for now, most studies excessively emphasized the one-sided factor on the change of synaptic plasticity participating in the generation of anxiety during the development of FXS. Here we proposed an integrated concept to acquire better recognition about the details of this process.http://dx.doi.org/10.1155/2016/9353929 |
| spellingShingle | Tao Yang Huan Zhao Changbo Lu Xiaoyu Li Yingli Xie Hao Fu Hui Xu Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome Neural Plasticity |
| title | Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome |
| title_full | Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome |
| title_fullStr | Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome |
| title_full_unstemmed | Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome |
| title_short | Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome |
| title_sort | synaptic plasticity a prominent contributor to the anxiety in fragile x syndrome |
| url | http://dx.doi.org/10.1155/2016/9353929 |
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