Elevated plasma CXCL12α is associated with a poorer prognosis in pulmonary arterial hypertension.

Elevated plasma CXCL12α is associated with a poorer prognosis in pulmonary arterial hypertension.

<h4>Rationale</h4>Recent work in preclinical models suggests that signalling via the pro-angiogenic and pro-inflammatory cytokine, CXCL12 (SDF-1), plays an important pathogenic role in pulmonary hypertension (PH). The objective of this study was to establish whether circulating concentra...

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Main Authors: Brian N McCullagh, Christine M Costello, Lili Li, Caroline O'Connell, Mary Codd, Allan Lawrie, Allison Morton, David G Kiely, Robin Condliffe, Charles Elliot, Paul McLoughlin, Sean Gaine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0123709
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https://doi.org/10.1371/journal.pone.0123709

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