Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights
Agricultural waste, such as empty fruit bunches (EFB) from palm oil production, poses environmental and health risks if not effectively managed. This study addresses this issue by innovatively transforming EFB biomass into high-value silver nanoparticles (AgNPs) via a green synthesis approach, marki...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Next Nanotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949829525000051 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589924530913280 |
|---|---|
| author | Bashirat Olamide Yusuf-Salihu Shakirat Afodun Abdulmumini Toheeb Taiye Bajepade Halimah Adekunbi Durosinmi Muinat Olanike Kazeem Victoria Atinuke Ajayi Agbaje Lateef |
| author_facet | Bashirat Olamide Yusuf-Salihu Shakirat Afodun Abdulmumini Toheeb Taiye Bajepade Halimah Adekunbi Durosinmi Muinat Olanike Kazeem Victoria Atinuke Ajayi Agbaje Lateef |
| author_sort | Bashirat Olamide Yusuf-Salihu |
| collection | DOAJ |
| description | Agricultural waste, such as empty fruit bunches (EFB) from palm oil production, poses environmental and health risks if not effectively managed. This study addresses this issue by innovatively transforming EFB biomass into high-value silver nanoparticles (AgNPs) via a green synthesis approach, marking the first successful biosynthesis of AgNPs from EFB. UV-Vis, FTIR, TEM, SAED, and EDX studies were used to characterize biosynthesized EFB-AgNPs. Biosynthesized EFB-AgNPs were tested for antibacterial, antioxidant, antidiabetic, anticoagulant, and thrombolytic activities. EFB-AgNPs showed a surface plasmon resonance peak at 477 nm, hydroxyl and amine group stabilization, and a silver content of 75.56 %. TEM and SAED analyses confirmed nanoscale particle diameters ranging from 12.78 nm to 19.10 nm, with a characteristic face-centered cubic (FCC) crystalline structure. EFB-AgNPs inhibited Escherichia coli, Klebsiella oxytoca, Staphylococcus aureus, Proteus mirabilis, and Pseudomonas aeruginosa dose-dependently from 40 % to 80 %, and 100 % of Aspergillus niger, A. fumigatus, and A. flavus. Reactive oxygen species (ROS) may cause cell membrane rupture and oxidative stress. Antioxidant testing demonstrated concentration-dependent activity across multiple assays: DPPH scavenging reached 81.49 % at 160 µg/ml, ferric-reducing activity was 90.05 % at 150 µg/ml, H₂O₂ scavenging achieved 91.00 % at 80 µg/ml, and NO scavenging reached 83.43 % at 150 µg/ml. Furthermore, EFB-AgNPs prevented blood coagulation and dissolved blood clots. In addition, EFB-AgNPs inhibited α-amylase with 74.64 % at 100 µg/ml. This unique approach of transforming EFB trash into high-value AgNPs could help sustain waste management and the circular bioeconomy by enabling medicinal applications. |
| format | Article |
| id | doaj-art-94c75e34ce9a4848a4c243b57ee47d66 |
| institution | Kabale University |
| issn | 2949-8295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Nanotechnology |
| spelling | doaj-art-94c75e34ce9a4848a4c243b57ee47d662025-01-24T04:46:08ZengElsevierNext Nanotechnology2949-82952025-01-017100136Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insightsBashirat Olamide Yusuf-Salihu0Shakirat Afodun Abdulmumini1Toheeb Taiye Bajepade2Halimah Adekunbi Durosinmi3Muinat Olanike Kazeem4Victoria Atinuke Ajayi5Agbaje Lateef6Department of Microbiology, Kwara State University, Malete, Kwara State, Nigeria; Corresponding author.Department of Microbiology, Kwara State University, Malete, Kwara State, NigeriaDepartment of Microbiology, Kwara State University, Malete, Kwara State, NigeriaDepartment of Microbiology, Kwara State University, Malete, Kwara State, NigeriaDepartment of Microbiology, Faculty of Life Sciences, University of Ilorin, Kwara State, NigeriaDepartment of Science Laboratory Technology, Ladoke Akintola University of Technology, Ogbomoso PMB 4000, NigeriaLaboratory of Industrial Microbiology and Nanobiotechnology, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, NigeriaAgricultural waste, such as empty fruit bunches (EFB) from palm oil production, poses environmental and health risks if not effectively managed. This study addresses this issue by innovatively transforming EFB biomass into high-value silver nanoparticles (AgNPs) via a green synthesis approach, marking the first successful biosynthesis of AgNPs from EFB. UV-Vis, FTIR, TEM, SAED, and EDX studies were used to characterize biosynthesized EFB-AgNPs. Biosynthesized EFB-AgNPs were tested for antibacterial, antioxidant, antidiabetic, anticoagulant, and thrombolytic activities. EFB-AgNPs showed a surface plasmon resonance peak at 477 nm, hydroxyl and amine group stabilization, and a silver content of 75.56 %. TEM and SAED analyses confirmed nanoscale particle diameters ranging from 12.78 nm to 19.10 nm, with a characteristic face-centered cubic (FCC) crystalline structure. EFB-AgNPs inhibited Escherichia coli, Klebsiella oxytoca, Staphylococcus aureus, Proteus mirabilis, and Pseudomonas aeruginosa dose-dependently from 40 % to 80 %, and 100 % of Aspergillus niger, A. fumigatus, and A. flavus. Reactive oxygen species (ROS) may cause cell membrane rupture and oxidative stress. Antioxidant testing demonstrated concentration-dependent activity across multiple assays: DPPH scavenging reached 81.49 % at 160 µg/ml, ferric-reducing activity was 90.05 % at 150 µg/ml, H₂O₂ scavenging achieved 91.00 % at 80 µg/ml, and NO scavenging reached 83.43 % at 150 µg/ml. Furthermore, EFB-AgNPs prevented blood coagulation and dissolved blood clots. In addition, EFB-AgNPs inhibited α-amylase with 74.64 % at 100 µg/ml. This unique approach of transforming EFB trash into high-value AgNPs could help sustain waste management and the circular bioeconomy by enabling medicinal applications.http://www.sciencedirect.com/science/article/pii/S2949829525000051Empty Fruit BunchSilver nanoparticlesGreen synthesisAnticoagulantAntimicrobial activityAntioxidant activity |
| spellingShingle | Bashirat Olamide Yusuf-Salihu Shakirat Afodun Abdulmumini Toheeb Taiye Bajepade Halimah Adekunbi Durosinmi Muinat Olanike Kazeem Victoria Atinuke Ajayi Agbaje Lateef Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights Next Nanotechnology Empty Fruit Bunch Silver nanoparticles Green synthesis Anticoagulant Antimicrobial activity Antioxidant activity |
| title | Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights |
| title_full | Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights |
| title_fullStr | Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights |
| title_full_unstemmed | Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights |
| title_short | Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights |
| title_sort | novel green synthesis of silver nanoparticles from empty fruit bunch waste biomedical applications and mechanistic insights |
| topic | Empty Fruit Bunch Silver nanoparticles Green synthesis Anticoagulant Antimicrobial activity Antioxidant activity |
| url | http://www.sciencedirect.com/science/article/pii/S2949829525000051 |
| work_keys_str_mv | AT bashiratolamideyusufsalihu novelgreensynthesisofsilvernanoparticlesfromemptyfruitbunchwastebiomedicalapplicationsandmechanisticinsights AT shakiratafodunabdulmumini novelgreensynthesisofsilvernanoparticlesfromemptyfruitbunchwastebiomedicalapplicationsandmechanisticinsights AT toheebtaiyebajepade novelgreensynthesisofsilvernanoparticlesfromemptyfruitbunchwastebiomedicalapplicationsandmechanisticinsights AT halimahadekunbidurosinmi novelgreensynthesisofsilvernanoparticlesfromemptyfruitbunchwastebiomedicalapplicationsandmechanisticinsights AT muinatolanikekazeem novelgreensynthesisofsilvernanoparticlesfromemptyfruitbunchwastebiomedicalapplicationsandmechanisticinsights AT victoriaatinukeajayi novelgreensynthesisofsilvernanoparticlesfromemptyfruitbunchwastebiomedicalapplicationsandmechanisticinsights AT agbajelateef novelgreensynthesisofsilvernanoparticlesfromemptyfruitbunchwastebiomedicalapplicationsandmechanisticinsights |