The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis

The open reading frame 3a (ORF3a) is a protein important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (160YNSV163, 211YYQL213, and 233YNKI236), and a previous study has indicated that mutation of the 160YNSV163 motif abrogated...

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Main Authors: Edward B. Stephens, Dusan Kunec, Wyatt Henke, Ricardo Martin Vidal, Brandon Greishaber, Rabina Saud, Maria Kalamvoki, Gagandeep Singh, Sujan Kafle, Jessie D. Trujillo, Franco Matias Ferreyra, Igor Morozov, Juergen A. Richt
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Viruses
Subjects:
SARS-CoV-2
ORF3a
tyrosine-based sorting motifs
intracellular transport
viroporin
viral pathogenesis
Online Access:https://www.mdpi.com/1999-4915/17/4/522
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