Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion
Background. Increasing evidence has revealed that mesenchymal stromal cell (MSC) transplantation alleviates hypoxic-ischemic brain damage (HIBD) induced neurological impairments via immunomodulating astrocyte antiapoptosis effects. However, it remains unclear whether MSCs regulate neuron autophagy f...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8822579 |
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| author | Miao Yang Wuqing Sun Lu Xiao Mulan He Yan Gu Ting Yang Jie Chen Xiaohua Liang |
| author_facet | Miao Yang Wuqing Sun Lu Xiao Mulan He Yan Gu Ting Yang Jie Chen Xiaohua Liang |
| author_sort | Miao Yang |
| collection | DOAJ |
| description | Background. Increasing evidence has revealed that mesenchymal stromal cell (MSC) transplantation alleviates hypoxic-ischemic brain damage (HIBD) induced neurological impairments via immunomodulating astrocyte antiapoptosis effects. However, it remains unclear whether MSCs regulate neuron autophagy following HIBD. Results. In the present study, MSC transplantation effectively ameliorated learning-memory function and suppressed stress-induced hippocampal neuron autophagy in HIBD rats. Moreover, the suppressive effects of MSCs on autophagy were significantly weakened following endogenous IL-6 silencing in MSCs. Suppressing IL-6 expression also significantly increased p-AMPK protein expression and decreased p-mTOR protein expression in injured hippocampal neurons. Conclusion. Endogenous IL-6 in MSCs may reduce autophagy in hippocampal neurons partly through the AMPK/mTOR pathway. |
| format | Article |
| id | doaj-art-946c9d55847849b9b797e5b92f33e2bf |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-946c9d55847849b9b797e5b92f33e2bf2025-02-03T01:08:11ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88225798822579Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 SecretionMiao Yang0Wuqing Sun1Lu Xiao2Mulan He3Yan Gu4Ting Yang5Jie Chen6Xiaohua Liang7Children’s Nutrition Research Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaChongqing Key Laboratory of Child Nutrition and Health, Chongqing 400014, ChinaChildren’s Nutrition Research Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaChildren’s Nutrition Research Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaChildren’s Nutrition Research Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaChildren’s Nutrition Research Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaChildren’s Nutrition Research Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaChildren’s Nutrition Research Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, ChinaBackground. Increasing evidence has revealed that mesenchymal stromal cell (MSC) transplantation alleviates hypoxic-ischemic brain damage (HIBD) induced neurological impairments via immunomodulating astrocyte antiapoptosis effects. However, it remains unclear whether MSCs regulate neuron autophagy following HIBD. Results. In the present study, MSC transplantation effectively ameliorated learning-memory function and suppressed stress-induced hippocampal neuron autophagy in HIBD rats. Moreover, the suppressive effects of MSCs on autophagy were significantly weakened following endogenous IL-6 silencing in MSCs. Suppressing IL-6 expression also significantly increased p-AMPK protein expression and decreased p-mTOR protein expression in injured hippocampal neurons. Conclusion. Endogenous IL-6 in MSCs may reduce autophagy in hippocampal neurons partly through the AMPK/mTOR pathway.http://dx.doi.org/10.1155/2020/8822579 |
| spellingShingle | Miao Yang Wuqing Sun Lu Xiao Mulan He Yan Gu Ting Yang Jie Chen Xiaohua Liang Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion Neural Plasticity |
| title | Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion |
| title_full | Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion |
| title_fullStr | Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion |
| title_full_unstemmed | Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion |
| title_short | Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion |
| title_sort | mesenchymal stromal cells suppress hippocampal neuron autophagy stress induced by hypoxic ischemic brain damage the possible role of endogenous il 6 secretion |
| url | http://dx.doi.org/10.1155/2020/8822579 |
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