Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.

Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.

The physiological role of fungal galectins has remained elusive. Here, we show that feeding of a mushroom galectin, Coprinopsis cinerea CGL2, to Caenorhabditis elegans inhibited development and reproduction and ultimately resulted in killing of this nematode. The lack of toxicity of a carbohydrate-b...

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Main Authors: Alex Butschi, Alexander Titz, Martin A Wälti, Vincent Olieric, Katharina Paschinger, Katharina Nöbauer, Xiaoqiang Guo, Peter H Seeberger, Iain B H Wilson, Markus Aebi, Michael O Hengartner, Markus Künzler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000717&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000717&type=printable

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