Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis

Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis

Abstract Protein tyrosine phosphatase mitochondrial 1 (PTPMT1), is a member of the protein tyrosine phosphatase superfamily localized on the mitochondrial inner membrane, and regulates the biosynthesis of cardiolipin. Given the important position of PTPMT1 in mitochondrial function and metabolism, p...

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Main Authors: Miaomiao Li, Yi Wang, Xinyan Li, Jiayi Xu, Liangwen Yan, Shenkang Tang, Chenyue Liu, Mengjiao Shi, Rongrong Liu, Yaping Zhao, Yi Zhang, Lan Yang, Yinggang Zhang, Gang Wang, Zongfang Li, Ying Guo, Yetong Feng, Pengfei Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07581-5
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https://doi.org/10.1038/s41419-025-07581-5

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