Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection

Changes in metabolite profiles in the cerebrospinal fluid and in human neuronal cells upon tick-borne encephalitis virus infection

Abstract Background Tick-borne encephalitis virus (TBEV) is a significant threat to human health. The virus causes potentially fatal disease of the central nervous system (CNS), for which no treatments are available. TBEV infected individuals display a wide spectrum of neuronal disease, the determin...

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Main Authors: Satoshi Suyama, Sally Boxall, Benjamin Grace, Andrea Fořtová, Martina Pychova, Lenka Krbkova, Rupasri Mandal, David Wishart, Diane E. Griffin, Daniel Růžek, Niluka Goonawardane
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Neuroinflammation
Subjects:
Tick-borne encephalitis virus
Cerebrospinal fluid
Human motor neurons
Metabolomics
Pro-inflammatory cytokines
Chemokines
Online Access:https://doi.org/10.1186/s12974-025-03478-4
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https://doi.org/10.1186/s12974-025-03478-4

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