Impact of Long COVID on Lung Function in Children
Objective: While the coronavirus disease-2019 (COVID-19) pandemic has generally resulted in milder illness among children than adults, persistent respiratory symptoms have been increasingly reported in this population. Methods: We conducted a prospective, single-center cohort study focusing on child...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-06-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-15853 |
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| author | Zeynep Reyhan ONAY Sinem CAN OKSAY Deniz MAVI TORTOP Gulay BILGIN Yetkin AYHAN Ferit DURANKUS Saniye GIRIT |
| author_facet | Zeynep Reyhan ONAY Sinem CAN OKSAY Deniz MAVI TORTOP Gulay BILGIN Yetkin AYHAN Ferit DURANKUS Saniye GIRIT |
| author_sort | Zeynep Reyhan ONAY |
| collection | DOAJ |
| description | Objective: While the coronavirus disease-2019 (COVID-19) pandemic has generally resulted in milder illness among children than adults, persistent respiratory symptoms have been increasingly reported in this population.
Methods: We conducted a prospective, single-center cohort study focusing on children experiencing prolonged respiratory symptoms after contracting COVID-19. Spirometry, 6- minute walk tests (6MWTs), and tests of lung volume, the diffusing capacity of the lungs for carbon monoxide (DLCO), and fractional exhaled nitric oxide (FeNO) were performed on COVID-19 survivors at least 4 weeks after infection and a group of healthy control subjects.
Results: Fifty-five children with long-term COVID and 55 healthy control subjects were recruited. The weight, height, and body mass index Z-scores were similar in the groups. Within a median duration of 85 days (minimum-maximum: 35-194) following COVID-19 infection, a restrictive pattern was observed to be more common in the study group (p=0.021). In children with long COVID, 6MWT distances, DLCO Z-scores, and the predicted values of spirometry and lung volume tests were found to be significantly lower but in the normal range. The average predicted values for DLCO, FeNO, and 6MWT were similar in the two groups.
Conclusions: Prolonged respiratory symptoms often persist long after COVID-19 infection, necessitating comprehensive evaluation of affected children. Close monitoring, including spirometry and lung volume assessments, is crucial for children with abnormalities in lung imaging. However, FeNO measurements were found to be ineffective in monitoring long COVID. |
| format | Article |
| id | doaj-art-93f6cc0f4ded41c6983f79310be199db |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-93f6cc0f4ded41c6983f79310be199db2025-01-29T10:24:23ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062024-06-01392748410.4274/MMJ.galenos.2024.15853MEDJ-15853Impact of Long COVID on Lung Function in ChildrenZeynep Reyhan ONAY0Sinem CAN OKSAY1Deniz MAVI TORTOP2Gulay BILGIN3Yetkin AYHAN4Ferit DURANKUS5Saniye GIRIT6Istanbul Medeniyet University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, TürkiyeIstanbul Medeniyet University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, TürkiyeIstanbul Medeniyet University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, TürkiyeIstanbul Medeniyet University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, TürkiyeIstanbul Medeniyet University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, TürkiyeIstanbul Medeniyet University Faculty of Medicine, Department of Pediatrics, Istanbul, TürkiyeIstanbul Medeniyet University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, TürkiyeObjective: While the coronavirus disease-2019 (COVID-19) pandemic has generally resulted in milder illness among children than adults, persistent respiratory symptoms have been increasingly reported in this population. Methods: We conducted a prospective, single-center cohort study focusing on children experiencing prolonged respiratory symptoms after contracting COVID-19. Spirometry, 6- minute walk tests (6MWTs), and tests of lung volume, the diffusing capacity of the lungs for carbon monoxide (DLCO), and fractional exhaled nitric oxide (FeNO) were performed on COVID-19 survivors at least 4 weeks after infection and a group of healthy control subjects. Results: Fifty-five children with long-term COVID and 55 healthy control subjects were recruited. The weight, height, and body mass index Z-scores were similar in the groups. Within a median duration of 85 days (minimum-maximum: 35-194) following COVID-19 infection, a restrictive pattern was observed to be more common in the study group (p=0.021). In children with long COVID, 6MWT distances, DLCO Z-scores, and the predicted values of spirometry and lung volume tests were found to be significantly lower but in the normal range. The average predicted values for DLCO, FeNO, and 6MWT were similar in the two groups. Conclusions: Prolonged respiratory symptoms often persist long after COVID-19 infection, necessitating comprehensive evaluation of affected children. Close monitoring, including spirometry and lung volume assessments, is crucial for children with abnormalities in lung imaging. However, FeNO measurements were found to be ineffective in monitoring long COVID.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-15853childrendiffusing capacityfractional exhaled nitric oxidelong covid6-minute walk test |
| spellingShingle | Zeynep Reyhan ONAY Sinem CAN OKSAY Deniz MAVI TORTOP Gulay BILGIN Yetkin AYHAN Ferit DURANKUS Saniye GIRIT Impact of Long COVID on Lung Function in Children Medeniyet Medical Journal children diffusing capacity fractional exhaled nitric oxide long covid 6-minute walk test |
| title | Impact of Long COVID on Lung Function in Children |
| title_full | Impact of Long COVID on Lung Function in Children |
| title_fullStr | Impact of Long COVID on Lung Function in Children |
| title_full_unstemmed | Impact of Long COVID on Lung Function in Children |
| title_short | Impact of Long COVID on Lung Function in Children |
| title_sort | impact of long covid on lung function in children |
| topic | children diffusing capacity fractional exhaled nitric oxide long covid 6-minute walk test |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-15853 |
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