Cysteine-Rich Protein 61 (CCN1) Deficiency Alleviated Cardiac Remodeling in 5/6 Nephrectomized Mice by Suppressing the MAPK Signaling Pathway

Conclusion: Our in vivo and in vitro study showed that specific CCN1 deficiency markedly alleviated cardiac remodeling in 5/6 Nx mice through the inhibition of the MAPK pathway.

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Bibliographic Details
Main Authors: Yihan Zhao, Liang Gu, Yunxuan Chen, Yibei Lin, Jincheng Xing, Diyan Xu, Zhen Su, Zhouqing Huang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Cardiovascular Therapeutics
Online Access:http://dx.doi.org/10.1155/cdr/6813183
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