IFP35, a novel DAMP, aggravates neuroinflammation following acute ischemic stroke via TLR4/NF-κB/NLRP3 signaling

IFP35, a novel DAMP, aggravates neuroinflammation following acute ischemic stroke via TLR4/NF-κB/NLRP3 signaling

Abstract Background Acute ischemic stroke is a disastrous disease characterized by damaging blood flow in the brain, leading to acute brain injury. Acute brain ischemia elicits severe inflammation, thus in turn, aggravates neural injury. Interferon-Induced Protein 35 (IFP35), is a 35 kDa protein, a...

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Main Authors: Mengmeng Zhang, Bingnan Guo, Xiaowei Zhang, Dong Han, Lanxin Lv, Xiaoqing Yan, Chenglei Su, Dafei Chai, Ningjun Zhao, Xianliang Yan, Shuqun Hu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Neuroinflammation
Subjects:
Interferon-Induced protein 35 (IFP35)
Damage-associated molecular patterns (DAMPs)
Neuroinflammation
Acute ischemic stroke
Online Access:https://doi.org/10.1186/s12974-025-03492-6
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https://doi.org/10.1186/s12974-025-03492-6

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