Molecular mechanism of pH sensing and activation in GPR4 reveals proton-mediated GPCR signaling

Molecular mechanism of pH sensing and activation in GPR4 reveals proton-mediated GPCR signaling

Abstract Maintaining pH homeostasis is critical for cellular function across all living organisms. Proton-sensing G protein-coupled receptors (GPCRs), particularly GPR4, play a pivotal role in cellular responses to pH changes. Yet, the molecular mechanisms underlying their proton sensing and activat...

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Main Authors: Chongzhao You, Shimeng Guo, Tianwei Zhang, Xinheng He, Tianyu Gao, Wenwen Xin, Zining Zhu, Yujie Lu, Youwei Xu, Zhen Li, Yumu Zhang, Xi Cheng, Yi Jiang, Xin Xie, H. Eric Xu
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00807-y
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https://doi.org/10.1038/s41421-025-00807-y

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