Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study
Aim. This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and M...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/348063 |
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| author | YanHong Dong Way Inn Koay Leonard Leong Litt Yeo Christopher Li-Hsian Chen Jing Xu Raymond Chee Seong Seet Erle Chuen Hian Lim |
| author_facet | YanHong Dong Way Inn Koay Leonard Leong Litt Yeo Christopher Li-Hsian Chen Jing Xu Raymond Chee Seong Seet Erle Chuen Hian Lim |
| author_sort | YanHong Dong |
| collection | DOAJ |
| description | Aim. This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) in detecting cognitive impairment (CI) in PD patients. Methods. One hundred and one PD patients were recruited from a movement disorders clinic in Singapore and they received the NINDS-CSN 5-minute protocol, MoCA, and MMSE. No cognitive impairment (NCI) was defined as Clinical Dementia Rating (CDR) = 0 and CI was defined as CDR ≥ 0.5. Results. Area under the receiver operating characteristic curve of NINDS-CSN 5-minute protocol was statistically equivalent to MoCA and larger than MMSE (0.86 versus 0.90, P=0.07; 0.86 versus 0.76, P=0.03). The sensitivity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) (0.77 versus 0.85, P=0.13) and superior to MMSE (<24) (0.77 versus 0.52, P<0.01) in detecting CI, while the specificity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) and MMSE (<24) (0.78 versus 0.88, P=0.34). Conclusion. The NINDS-CSN 5-minute protocol is time expeditious while remaining statistically equivalent to MoCA and superior to MMSE and therefore is suitable for rapid cognitive screening of CI in PD patients. |
| format | Article |
| id | doaj-art-92c8c115c0eb43ff8f10842a193b694f |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-92c8c115c0eb43ff8f10842a193b694f2025-02-03T01:23:38ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/348063348063Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot StudyYanHong Dong0Way Inn Koay1Leonard Leong Litt Yeo2Christopher Li-Hsian Chen3Jing Xu4Raymond Chee Seong Seet5Erle Chuen Hian Lim6Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, 117600, SingaporeDivision of Neurology, National University Hospital, 5 Lower Kent Ridge Road, 119074, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, BLK MD3 Level 4 #04-01, 16 Medical Drive, 117600, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University Health System, 1E, Level 10, NUHS Tower Block, Kent Ridge Road, 119228, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University Health System, 1E, Level 10, NUHS Tower Block, Kent Ridge Road, 119228, SingaporeAim. This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) in detecting cognitive impairment (CI) in PD patients. Methods. One hundred and one PD patients were recruited from a movement disorders clinic in Singapore and they received the NINDS-CSN 5-minute protocol, MoCA, and MMSE. No cognitive impairment (NCI) was defined as Clinical Dementia Rating (CDR) = 0 and CI was defined as CDR ≥ 0.5. Results. Area under the receiver operating characteristic curve of NINDS-CSN 5-minute protocol was statistically equivalent to MoCA and larger than MMSE (0.86 versus 0.90, P=0.07; 0.86 versus 0.76, P=0.03). The sensitivity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) (0.77 versus 0.85, P=0.13) and superior to MMSE (<24) (0.77 versus 0.52, P<0.01) in detecting CI, while the specificity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) and MMSE (<24) (0.78 versus 0.88, P=0.34). Conclusion. The NINDS-CSN 5-minute protocol is time expeditious while remaining statistically equivalent to MoCA and superior to MMSE and therefore is suitable for rapid cognitive screening of CI in PD patients.http://dx.doi.org/10.1155/2015/348063 |
| spellingShingle | YanHong Dong Way Inn Koay Leonard Leong Litt Yeo Christopher Li-Hsian Chen Jing Xu Raymond Chee Seong Seet Erle Chuen Hian Lim Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study Parkinson's Disease |
| title | Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study |
| title_full | Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study |
| title_fullStr | Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study |
| title_full_unstemmed | Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study |
| title_short | Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study |
| title_sort | rapid screening for cognitive impairment in parkinson s disease a pilot study |
| url | http://dx.doi.org/10.1155/2015/348063 |
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