Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases
Asprosin is a white adipose tissue-derived hormone that increases abnormally in mammals with insulin resistance. However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and its potential connection with type 2 diabetes mellitus (T2DM)...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7375294 |
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| author | Xing Li Mingyu Liao Rufei Shen Linlin Zhang Hua Hu Jun Wu Xiuli Wang Hua Qu Shaodong Guo Min Long Hongting Zheng |
| author_facet | Xing Li Mingyu Liao Rufei Shen Linlin Zhang Hua Hu Jun Wu Xiuli Wang Hua Qu Shaodong Guo Min Long Hongting Zheng |
| author_sort | Xing Li |
| collection | DOAJ |
| description | Asprosin is a white adipose tissue-derived hormone that increases abnormally in mammals with insulin resistance. However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and its potential connection with type 2 diabetes mellitus (T2DM) and PCOS has not been thoroughly elucidated to date. To investigate the association of asprosin with metabolic profiles, sex-related hormones, or inflammation in females with T2DM or PCOS, plasma asprosin and metabolic indicators were measured in 66 healthy females, 53 female patients with T2DM, and 41 patients with PCOS. Spearman’s correlation analysis and binary logistic regression analysis models were used. Plasma asprosin was significantly higher in T2DM females than in healthy subjects (P<0.001) and was positively correlated with fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and HOMA-IR (P<0.05). Asprosin in PCOS subjects was also higher than in healthy subjects (P<0.001) but lower than in T2DM subjects (P<0.05), and it was positively correlated with FBG, HbA1c, HOMA-IR, LDL-c, APOB, APOE, and testosterone (P<0.05). The BMI-categorized subgroups of PCOS subjects also showed correlations of asprosin with metabolic profiles and sex-related hormones. Binary logistic regression analysis revealed that plasma asprosin level acted as an independent risk factor for T2DM or PCOS. These findings suggest the correlation of plasma asprosin level with glucose metabolism, lipid metabolism, sex-related hormones, and inflammation in females, supporting asprosin as a potential predictive factor for females with metabolic-related diseases. This trial is registered with ChiCTR-ROC-17010719. |
| format | Article |
| id | doaj-art-92c7cdf9d869402c90ea044d1766ed1c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-92c7cdf9d869402c90ea044d1766ed1c2025-02-03T01:11:42ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/73752947375294Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related DiseasesXing Li0Mingyu Liao1Rufei Shen2Linlin Zhang3Hua Hu4Jun Wu5Xiuli Wang6Hua Qu7Shaodong Guo8Min Long9Hongting Zheng10Department of Endocrinology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Endocrinology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Endocrinology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Endocrinology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Obstetrics and Gynecology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Health Management, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Health Management, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Endocrinology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Nutrition and Food Science College of Agriculture and Life Sciences, Texas A&M University, Texas 77843, USADepartment of Endocrinology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaDepartment of Endocrinology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, ChinaAsprosin is a white adipose tissue-derived hormone that increases abnormally in mammals with insulin resistance. However, the role of asprosin in polycystic ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and its potential connection with type 2 diabetes mellitus (T2DM) and PCOS has not been thoroughly elucidated to date. To investigate the association of asprosin with metabolic profiles, sex-related hormones, or inflammation in females with T2DM or PCOS, plasma asprosin and metabolic indicators were measured in 66 healthy females, 53 female patients with T2DM, and 41 patients with PCOS. Spearman’s correlation analysis and binary logistic regression analysis models were used. Plasma asprosin was significantly higher in T2DM females than in healthy subjects (P<0.001) and was positively correlated with fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and HOMA-IR (P<0.05). Asprosin in PCOS subjects was also higher than in healthy subjects (P<0.001) but lower than in T2DM subjects (P<0.05), and it was positively correlated with FBG, HbA1c, HOMA-IR, LDL-c, APOB, APOE, and testosterone (P<0.05). The BMI-categorized subgroups of PCOS subjects also showed correlations of asprosin with metabolic profiles and sex-related hormones. Binary logistic regression analysis revealed that plasma asprosin level acted as an independent risk factor for T2DM or PCOS. These findings suggest the correlation of plasma asprosin level with glucose metabolism, lipid metabolism, sex-related hormones, and inflammation in females, supporting asprosin as a potential predictive factor for females with metabolic-related diseases. This trial is registered with ChiCTR-ROC-17010719.http://dx.doi.org/10.1155/2018/7375294 |
| spellingShingle | Xing Li Mingyu Liao Rufei Shen Linlin Zhang Hua Hu Jun Wu Xiuli Wang Hua Qu Shaodong Guo Min Long Hongting Zheng Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases Mediators of Inflammation |
| title | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
| title_full | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
| title_fullStr | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
| title_full_unstemmed | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
| title_short | Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases |
| title_sort | plasma asprosin levels are associated with glucose metabolism lipid and sex hormone profiles in females with metabolic related diseases |
| url | http://dx.doi.org/10.1155/2018/7375294 |
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