Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation

Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation

Microtubule-associated protein tau is inextricably linked to a group of clinically diverse neurodegenerative diseases termed tauopathies. The ratio balance of the major tau splicing isoform groups (3 R- and 4 R-tau) is critical in maintaining healthy neurons. An imbalance causing excess 4 R tau is a...

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Bibliographic Details
Main Authors: Dale O. Starkie, Charles Arber, Terry Baker, Daniel J. Lightwood, Selina Wray
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Antibody Discovery
degrabodies
degrading antibody fragments
intracellular antibody technologies
iPSC-derrived neurons
targeted protein degradation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2436102
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https://www.tandfonline.com/doi/10.1080/19420862.2024.2436102

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