Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

Abstract The complex of Vacuolar Protein Sorting 34 and 15 (Vps34 and Vps15) has Class III phosphatidylinositol 3‐kinase activity and putative roles in nutrient sensing, mammalian Target Of Rapamycin (mTOR) activation by amino acids, cell growth, vesicular trafficking and autophagy. Contrary to expe...

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Main Authors: Ivan Nemazanyy, Bert Blaauw, Cecilia Paolini, Catherine Caillaud, Feliciano Protasi, Amelie Mueller, Tassula Proikas‐Cezanne, Ryan C. Russell, Kun‐Liang Guan, Ichizo Nishino, Marco Sandri, Mario Pende, Ganna Panasyuk
Format: Article
Language:English
Published: Springer Nature 2013-04-01
Series:EMBO Molecular Medicine
Subjects:
autophagy
human disease
lysosomal storage disease
mouse model
mTOR signalling
Online Access:https://doi.org/10.1002/emmm.201202057
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https://doi.org/10.1002/emmm.201202057

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