Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry.

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry.

Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner. We and others have previously shown that ACE2 orthologs from New World monkey, koala and mouse...

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Main Authors: Wenlin Ren, Yunkai Zhu, Yuyan Wang, Hongyang Shi, Yin Yu, Gaowei Hu, Fei Feng, Xiaomin Zhao, Jun Lan, Jianping Wu, Devin J Kenney, Florian Douam, Yimin Tong, Jin Zhong, Youhua Xie, Xinquan Wang, Zhenghong Yuan, Dongming Zhou, Rong Zhang, Qiang Ding
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009392&type=printable
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