Less reactogenic whole-cell pertussis vaccine confers protection from Bordetella pertussis infection

Less reactogenic whole-cell pertussis vaccine confers protection from Bordetella pertussis infection

ABSTRACT Pertussis resurged over the last decade in most countries that replaced the traditional whole-cell pertussis vaccines (wP) by the less reactogenic acellular pertussis vaccines (aP). The aP vaccines induce a Th2-polarized immune response and by a yet unknown mechanism hamper the clearance of...

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Bibliographic Details
Main Authors: Karolína Škopová, Jana Holubová, Barbora Bočková, Eva Slivenecká, João Melo Santos de Barros, Ondřej Staněk, Peter Šebo
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mSphere
Subjects:
Bordetella pertussis
whooping cough
whole-cell vaccine
reactogenicity
immunogenicity
protection
Online Access:https://journals.asm.org/doi/10.1128/msphere.00639-24
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https://journals.asm.org/doi/10.1128/msphere.00639-24

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