Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/2373902 |
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| author | Kohei Kasahara Masahiro Onozawa Naohiro Miyashita Emi Yokohata Miho Yoshida Minoru Kanaya Mizuha Kosugi-Kanaya Ryo Takemura Shojiro Takahashi Junichi Sugita Akio Shigematsu Mutsumi Takahata Shinichi Fujisawa Daigo Hashimoto Katsuya Fujimoto Tomoyuki Endo Takeshi Kondo Takanori Teshima |
| author_facet | Kohei Kasahara Masahiro Onozawa Naohiro Miyashita Emi Yokohata Miho Yoshida Minoru Kanaya Mizuha Kosugi-Kanaya Ryo Takemura Shojiro Takahashi Junichi Sugita Akio Shigematsu Mutsumi Takahata Shinichi Fujisawa Daigo Hashimoto Katsuya Fujimoto Tomoyuki Endo Takeshi Kondo Takanori Teshima |
| author_sort | Kohei Kasahara |
| collection | DOAJ |
| description | We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after induction therapy showed 45,XY,-7,inv(9)(p12q13)c[19]/46,XY,inv(9)(p12q13)c[1]. Retrospective FISH analysis revealed a cryptic monosomy 7 clone in the initial AML sample. The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage. Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7. We concluded that one clone was de novo AMoL with chromosome 6, 8, 11, 13, and 19 trisomy and that the other was acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) with chromosome 7 monosomy showing different responses to chemotherapy. Simultaneous onset of cytogenetically unrelated hematological malignancies that each have a different disease status is a rare phenomenon but is important to diagnose for a correct understanding of the disease status and for establishing an appropriate treatment strategy. |
| format | Article |
| id | doaj-art-922d890280d540f1b3e336bddaf6d15b |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-922d890280d540f1b3e336bddaf6d15b2025-02-03T01:32:33ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/23739022373902Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to ChemotherapyKohei Kasahara0Masahiro Onozawa1Naohiro Miyashita2Emi Yokohata3Miho Yoshida4Minoru Kanaya5Mizuha Kosugi-Kanaya6Ryo Takemura7Shojiro Takahashi8Junichi Sugita9Akio Shigematsu10Mutsumi Takahata11Shinichi Fujisawa12Daigo Hashimoto13Katsuya Fujimoto14Tomoyuki Endo15Takeshi Kondo16Takanori Teshima17Department of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanDepartment of Hematology, Hokkaido University Hospital, Sapporo 060-8638, JapanWe report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after induction therapy showed 45,XY,-7,inv(9)(p12q13)c[19]/46,XY,inv(9)(p12q13)c[1]. Retrospective FISH analysis revealed a cryptic monosomy 7 clone in the initial AML sample. The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage. Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7. We concluded that one clone was de novo AMoL with chromosome 6, 8, 11, 13, and 19 trisomy and that the other was acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) with chromosome 7 monosomy showing different responses to chemotherapy. Simultaneous onset of cytogenetically unrelated hematological malignancies that each have a different disease status is a rare phenomenon but is important to diagnose for a correct understanding of the disease status and for establishing an appropriate treatment strategy.http://dx.doi.org/10.1155/2016/2373902 |
| spellingShingle | Kohei Kasahara Masahiro Onozawa Naohiro Miyashita Emi Yokohata Miho Yoshida Minoru Kanaya Mizuha Kosugi-Kanaya Ryo Takemura Shojiro Takahashi Junichi Sugita Akio Shigematsu Mutsumi Takahata Shinichi Fujisawa Daigo Hashimoto Katsuya Fujimoto Tomoyuki Endo Takeshi Kondo Takanori Teshima Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy Case Reports in Hematology |
| title | Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy |
| title_full | Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy |
| title_fullStr | Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy |
| title_full_unstemmed | Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy |
| title_short | Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy |
| title_sort | cytogenetically unrelated clones in acute myeloid leukemia showing different responses to chemotherapy |
| url | http://dx.doi.org/10.1155/2016/2373902 |
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