Season of conception and risk of hypertensive disorder during pregnancy
Abstract Background Hypertensive Disorder during Pregnancy (HDP) is the most prevalent obstetric conditions in maternal health, but the etiology of most cases remains unexplained. Seasonal variations in the conception of HDP may offer insights into the potential seasonal-specific risk factors. Metho...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-025-07210-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571251317538816 |
|---|---|
| author | Yanxia Xie Yi Mu Peiran Chen Yanping Wang Xiaohong Li Li Dai Zheng Liu Qi Li Mingrong Li Juan Liang Jun Zhu |
| author_facet | Yanxia Xie Yi Mu Peiran Chen Yanping Wang Xiaohong Li Li Dai Zheng Liu Qi Li Mingrong Li Juan Liang Jun Zhu |
| author_sort | Yanxia Xie |
| collection | DOAJ |
| description | Abstract Background Hypertensive Disorder during Pregnancy (HDP) is the most prevalent obstetric conditions in maternal health, but the etiology of most cases remains unexplained. Seasonal variations in the conception of HDP may offer insights into the potential seasonal-specific risk factors. Methods Data were sourced from the China’s National Maternal Near Miss Surveillance System (NMNMSS) between January 1, 2012, and December 31, 2021. HDP status was ascertained from the diagnostic records over 400 medical institutions. The conception date was estimated based on the delivery date and duration of gestation length, and the season of conception, were categorised as winter (December to February), spring (March to May), summer (June to August), and fall (September to November). Odd ratios were calculated separately using the logistic regression model. Results Among the 14,073,565 pregnant women analysed, 3.98% met the study’s criteria for HDP as defined in the present study. Maternal conception in spring was associated with a 10% increased risk of HDP (aOR, 1.10 [95% CI, 1.08–1.12]) compared with summer conceptions. Elevated risk of HDP was observed for maternal individuals conceiving in February, March, April, May, and June according to analyses conducted for specific months. The associations were slightly stronger in the subgroup of women diagnosed with gestational hypertension and preeclampsia. Significant disparities exist in this association among the diverse Köppen-Geiger climate zones. Conclusion Significant seasonal variations in the risk for HDP were observed across a range of maternal characteristics, HDP subtypes, and climatc zones. These findings imply the necessity of considering seasonally fluctuating environmental factors in the etiological investigation of HDP. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-918c738a8c284ec2af16524f9d11536b |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-918c738a8c284ec2af16524f9d11536b2025-02-02T12:46:57ZengBMCBMC Pregnancy and Childbirth1471-23932025-01-0125111110.1186/s12884-025-07210-1Season of conception and risk of hypertensive disorder during pregnancyYanxia Xie0Yi Mu1Peiran Chen2Yanping Wang3Xiaohong Li4Li Dai5Zheng Liu6Qi Li7Mingrong Li8Juan Liang9Jun Zhu10National Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityNational Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan UniversityAbstract Background Hypertensive Disorder during Pregnancy (HDP) is the most prevalent obstetric conditions in maternal health, but the etiology of most cases remains unexplained. Seasonal variations in the conception of HDP may offer insights into the potential seasonal-specific risk factors. Methods Data were sourced from the China’s National Maternal Near Miss Surveillance System (NMNMSS) between January 1, 2012, and December 31, 2021. HDP status was ascertained from the diagnostic records over 400 medical institutions. The conception date was estimated based on the delivery date and duration of gestation length, and the season of conception, were categorised as winter (December to February), spring (March to May), summer (June to August), and fall (September to November). Odd ratios were calculated separately using the logistic regression model. Results Among the 14,073,565 pregnant women analysed, 3.98% met the study’s criteria for HDP as defined in the present study. Maternal conception in spring was associated with a 10% increased risk of HDP (aOR, 1.10 [95% CI, 1.08–1.12]) compared with summer conceptions. Elevated risk of HDP was observed for maternal individuals conceiving in February, March, April, May, and June according to analyses conducted for specific months. The associations were slightly stronger in the subgroup of women diagnosed with gestational hypertension and preeclampsia. Significant disparities exist in this association among the diverse Köppen-Geiger climate zones. Conclusion Significant seasonal variations in the risk for HDP were observed across a range of maternal characteristics, HDP subtypes, and climatc zones. These findings imply the necessity of considering seasonally fluctuating environmental factors in the etiological investigation of HDP. Clinical trial number Not applicable.https://doi.org/10.1186/s12884-025-07210-1Hypertensive disorder during pregnancySeasonConceptionKöppen-Geiger |
| spellingShingle | Yanxia Xie Yi Mu Peiran Chen Yanping Wang Xiaohong Li Li Dai Zheng Liu Qi Li Mingrong Li Juan Liang Jun Zhu Season of conception and risk of hypertensive disorder during pregnancy BMC Pregnancy and Childbirth Hypertensive disorder during pregnancy Season Conception Köppen-Geiger |
| title | Season of conception and risk of hypertensive disorder during pregnancy |
| title_full | Season of conception and risk of hypertensive disorder during pregnancy |
| title_fullStr | Season of conception and risk of hypertensive disorder during pregnancy |
| title_full_unstemmed | Season of conception and risk of hypertensive disorder during pregnancy |
| title_short | Season of conception and risk of hypertensive disorder during pregnancy |
| title_sort | season of conception and risk of hypertensive disorder during pregnancy |
| topic | Hypertensive disorder during pregnancy Season Conception Köppen-Geiger |
| url | https://doi.org/10.1186/s12884-025-07210-1 |
| work_keys_str_mv | AT yanxiaxie seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT yimu seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT peiranchen seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT yanpingwang seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT xiaohongli seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT lidai seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT zhengliu seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT qili seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT mingrongli seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT juanliang seasonofconceptionandriskofhypertensivedisorderduringpregnancy AT junzhu seasonofconceptionandriskofhypertensivedisorderduringpregnancy |