Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering
The anterior cruciate ligament (ACL) is one of the most injured ligaments, with approximately 100,000 ACL reconstructions taking place annually in the United States. In order to successfully manage ACL rupture, it is of the utmost importance to understand the anatomy, unique physiology, and biomecha...
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MDPI AG
2025-01-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/12/1/39 |
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| author | Aris Sopilidis Vasileios Stamatopoulos Vasileios Giannatos Georgios Taraviras Andreas Panagopoulos Stavros Taraviras |
| author_facet | Aris Sopilidis Vasileios Stamatopoulos Vasileios Giannatos Georgios Taraviras Andreas Panagopoulos Stavros Taraviras |
| author_sort | Aris Sopilidis |
| collection | DOAJ |
| description | The anterior cruciate ligament (ACL) is one of the most injured ligaments, with approximately 100,000 ACL reconstructions taking place annually in the United States. In order to successfully manage ACL rupture, it is of the utmost importance to understand the anatomy, unique physiology, and biomechanics of the ACL, as well as the injury mechanisms and healing capacity. Currently, the “gold standard” for the treatment of ACL ruptures is surgical reconstruction, particularly for young patients or athletes expecting to return to pivoting sports. Although ACL reconstruction boasts a high success rate, patients may face different, serious post-operative complications, depending on the type of graft and technique used in each one of them. Tissue engineering is a multidisciplinary field that could contribute to the formation of a tissue-engineered ACL graft manufactured by a combination of the appropriate stem-cell type, a suitable scaffold, and specific growth factors, combined with mechanical stimuli. In this review, we discuss the aspects that constitute the creation of a successful tissue-engineered graft while also underlining the current drawbacks that arise for each issue. Finally, we highlight the benefits of incorporating new technologies like artificial intelligence and machine learning that could revolutionize tissue engineering. |
| format | Article |
| id | doaj-art-9159b1f0fabb4e47a9df9001e53256fd |
| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-9159b1f0fabb4e47a9df9001e53256fd2025-01-24T13:23:03ZengMDPI AGBioengineering2306-53542025-01-011213910.3390/bioengineering12010039Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue EngineeringAris Sopilidis0Vasileios Stamatopoulos1Vasileios Giannatos2Georgios Taraviras3Andreas Panagopoulos4Stavros Taraviras5Department of Physiology, School of Medicine, University of Patras, Asklepiou Street 1, Rio, 26504 Patras, GreeceDepartment of Physiology, School of Medicine, University of Patras, Asklepiou Street 1, Rio, 26504 Patras, GreeceDepartment of Orthopedics and Traumatology, Sports Medicine Department, University Hospital of Patras, Asklepiou Street 1, Rio, 26504 Patras, GreeceDepartment of Physiology, School of Medicine, University of Patras, Asklepiou Street 1, Rio, 26504 Patras, GreeceDepartment of Orthopedics and Traumatology, Sports Medicine Department, University Hospital of Patras, Asklepiou Street 1, Rio, 26504 Patras, GreeceDepartment of Physiology, School of Medicine, University of Patras, Asklepiou Street 1, Rio, 26504 Patras, GreeceThe anterior cruciate ligament (ACL) is one of the most injured ligaments, with approximately 100,000 ACL reconstructions taking place annually in the United States. In order to successfully manage ACL rupture, it is of the utmost importance to understand the anatomy, unique physiology, and biomechanics of the ACL, as well as the injury mechanisms and healing capacity. Currently, the “gold standard” for the treatment of ACL ruptures is surgical reconstruction, particularly for young patients or athletes expecting to return to pivoting sports. Although ACL reconstruction boasts a high success rate, patients may face different, serious post-operative complications, depending on the type of graft and technique used in each one of them. Tissue engineering is a multidisciplinary field that could contribute to the formation of a tissue-engineered ACL graft manufactured by a combination of the appropriate stem-cell type, a suitable scaffold, and specific growth factors, combined with mechanical stimuli. In this review, we discuss the aspects that constitute the creation of a successful tissue-engineered graft while also underlining the current drawbacks that arise for each issue. Finally, we highlight the benefits of incorporating new technologies like artificial intelligence and machine learning that could revolutionize tissue engineering.https://www.mdpi.com/2306-5354/12/1/39anterior cruciate ligamentanterior cruciate ligament reconstructionscaffoldtissue engineeringartificial intelligencestem cells |
| spellingShingle | Aris Sopilidis Vasileios Stamatopoulos Vasileios Giannatos Georgios Taraviras Andreas Panagopoulos Stavros Taraviras Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering Bioengineering anterior cruciate ligament anterior cruciate ligament reconstruction scaffold tissue engineering artificial intelligence stem cells |
| title | Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering |
| title_full | Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering |
| title_fullStr | Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering |
| title_full_unstemmed | Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering |
| title_short | Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering |
| title_sort | integrating modern technologies into traditional anterior cruciate ligament tissue engineering |
| topic | anterior cruciate ligament anterior cruciate ligament reconstruction scaffold tissue engineering artificial intelligence stem cells |
| url | https://www.mdpi.com/2306-5354/12/1/39 |
| work_keys_str_mv | AT arissopilidis integratingmoderntechnologiesintotraditionalanteriorcruciateligamenttissueengineering AT vasileiosstamatopoulos integratingmoderntechnologiesintotraditionalanteriorcruciateligamenttissueengineering AT vasileiosgiannatos integratingmoderntechnologiesintotraditionalanteriorcruciateligamenttissueengineering AT georgiostaraviras integratingmoderntechnologiesintotraditionalanteriorcruciateligamenttissueengineering AT andreaspanagopoulos integratingmoderntechnologiesintotraditionalanteriorcruciateligamenttissueengineering AT stavrostaraviras integratingmoderntechnologiesintotraditionalanteriorcruciateligamenttissueengineering |