DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2

DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2

DDX3 is a DEAD‐box RNA helicase that plays multiple roles in RNA metabolism, including translation. We previously reported that DDX3 is required for translation of PACT, a binding partner of Dicer, suggesting a role for DDX3 in microRNA (miRNA) biogenesis and RNA interference (RNAi). Emerging eviden...

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Bibliographic Details
Main Authors: Ming‐Chih Lai, Yen‐Ling Yu, Chiao‐Nung Chen, Jau‐Song Yu, Hsin‐Yuan Hung, Shih‐Peng Chan
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:FEBS Open Bio
Subjects:
cancer development
DEAD‐box RNA helicase
miRNA biogenesis
RNA interference
translational control
Online Access:https://doi.org/10.1002/2211-5463.13920
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https://doi.org/10.1002/2211-5463.13920

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