ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma

Abstract Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High‐fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis. How HCC cells regulate ROS level and escape the cytotoxic effects of hig...

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Main Authors: Xinran Liu, Qiujin Ma, Zhao Jia, Yihao Zhou, Churong Zou, Yushuo Xiao, Yuchen Chen, Chuyao Ma, Liangliang Song, Jing Yang, Chen Wang, Huidie Xu, Hong Chen, Jiajian Shi, Junqiu Yue, Yu Sun, Desheng Hu, Robert B Petersen, Yangkai Li, Anlin Peng, Kun Huang, Ling Zheng
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
γ‐glutamate cysteine ligase
glutathione
hepatocellular carcinoma
high fat diet
interferon stimulated gene 15
reactive oxygen species
Online Access:https://doi.org/10.1002/advs.202416401
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https://doi.org/10.1002/advs.202416401

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