Isoetin from Isoetaceae Exhibits Superior Pentatransferase Inhibition in Breast Cancer: Comparative Computational Profiling with FDA-Approved Tucatinib

Isoetin from Isoetaceae Exhibits Superior Pentatransferase Inhibition in Breast Cancer: Comparative Computational Profiling with FDA-Approved Tucatinib

<b>Background:</b> Breast cancer, the most prevalent cancer among women globally, develops primarily in the breast’s ducts or lobules. Drug resistance is a significant challenge in treating advanced cases, contributing to over 685,000 breast cancer-related deaths annually, and identifyin...

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Main Authors: Abdulaziz H. Al Khzem, Mansour S. Alturki, Ohood K. Almuzaini, Saad M. Wali, Mohammed Almaghrabi, Mohammed F. Aldawsari, Maram H. Abduljabbar, Reem M. Alnemari, Atiah H. Almalki, Thankhoe A. Rants’o
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
breast cancer resistance
Isoetin
tucatinib
WaterMap
binding free energy
Online Access:https://www.mdpi.com/1424-8247/18/5/662
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