Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil
Cardiovascular disease has emerged as a crescent problem among HIV-infected population. This study aimed to determine the 10-year risk of coronary heart disease using the Framingham risk score among HIV-infected patients from three regions of Brazil. This is a pooled analysis of three cohort studies...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/163418 |
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| author | Sandra C. Fuchs Paulo R. Alencastro Maria Letícia R. Ikeda Nêmora T. Barcellos Fernando H. Wolff Ajácio B. M. Brandão Ricardo A. A. Ximenes Demócrito de B. Miranda-Filho Heloísa Ramos Lacerda Maria de Fátima P. M. de Albuquerque Ulisses Ramos Montarroyos Max W. Nery Marilia D. Turchi |
| author_facet | Sandra C. Fuchs Paulo R. Alencastro Maria Letícia R. Ikeda Nêmora T. Barcellos Fernando H. Wolff Ajácio B. M. Brandão Ricardo A. A. Ximenes Demócrito de B. Miranda-Filho Heloísa Ramos Lacerda Maria de Fátima P. M. de Albuquerque Ulisses Ramos Montarroyos Max W. Nery Marilia D. Turchi |
| author_sort | Sandra C. Fuchs |
| collection | DOAJ |
| description | Cardiovascular disease has emerged as a crescent problem among HIV-infected population. This study aimed to determine the 10-year risk of coronary heart disease using the Framingham risk score among HIV-infected patients from three regions of Brazil. This is a pooled analysis of three cohort studies, which enrolled 3,829 individuals, 59% were men, 66% had white skin color, and mean age 39.0 ± 9.9 years. Comparisons among regions showed that there were marked differences in demographic, socioeconomic, clinical, and HIV-related characteristics. Prevalence of Framingham score ≥10 was 4.5% in the Southern, 4.2% in the Midwest, and 3.9% in the Northeast of Brazil. The Framingham score ≥10 was similar between regions for males, patients aged ≥60 years, with obesity, central obesity, hypertension, and diabetes mellitus. Women were three times more likely to have coronary heart disease in 10 years than men. Hypertension and diabetes increased more than four times the risk of coronary heart disease, followed by central obesity, obesity, and prehypertension. The use of antiretroviral agents and time since HIV diagnosis were not risk factors for coronary artery disease in 10 years. In conclusion, hypertension and diabetes are the strongest independent predictors of 10-year risk of coronary heart disease among HIV-infected population. |
| format | Article |
| id | doaj-art-905aea5fe2d345888d7178b6abbc332b |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-905aea5fe2d345888d7178b6abbc332b2025-02-03T01:00:51ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/163418163418Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in BrazilSandra C. Fuchs0Paulo R. Alencastro1Maria Letícia R. Ikeda2Nêmora T. Barcellos3Fernando H. Wolff4Ajácio B. M. Brandão5Ricardo A. A. Ximenes6Demócrito de B. Miranda-Filho7Heloísa Ramos Lacerda8Maria de Fátima P. M. de Albuquerque9Ulisses Ramos Montarroyos10Max W. Nery11Marilia D. Turchi12Postgraduate Studies Program in Cardiology, School of Medicine, Clinical Research Center, No. 5 Andar, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, BrazilNational Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clinicas de Porto Alegre, 90035-903 Porto Alegre, RS, BrazilPostgraduate Studies Program in Cardiology, School of Medicine, Clinical Research Center, No. 5 Andar, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, BrazilPostgraduate Studies Program in Cardiology, School of Medicine, Clinical Research Center, No. 5 Andar, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, BrazilPostgraduate Studies Program in Cardiology, School of Medicine, Clinical Research Center, No. 5 Andar, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, BrazilNational Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clinicas de Porto Alegre, 90035-903 Porto Alegre, RS, BrazilNational Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clinicas de Porto Alegre, 90035-903 Porto Alegre, RS, BrazilNational Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clinicas de Porto Alegre, 90035-903 Porto Alegre, RS, BrazilDepartment of Tropical Medicine, Universidade Federal de Pernambuco, 50610-110 Recife, PE, BrazilResearch Center Aggeu Magalhães, Fundação Oswaldo Cruz, 50.670-420 Recife, PE, BrazilInstitute of Biological Sciences, Universidade de Pernambuco, 50670-901 Recife, PE, BrazilInstitute of Tropical Pathology and Public Health, Universidade Federal de Goiás, 74605050 Goiania, GO, BrazilNational Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clinicas de Porto Alegre, 90035-903 Porto Alegre, RS, BrazilCardiovascular disease has emerged as a crescent problem among HIV-infected population. This study aimed to determine the 10-year risk of coronary heart disease using the Framingham risk score among HIV-infected patients from three regions of Brazil. This is a pooled analysis of three cohort studies, which enrolled 3,829 individuals, 59% were men, 66% had white skin color, and mean age 39.0 ± 9.9 years. Comparisons among regions showed that there were marked differences in demographic, socioeconomic, clinical, and HIV-related characteristics. Prevalence of Framingham score ≥10 was 4.5% in the Southern, 4.2% in the Midwest, and 3.9% in the Northeast of Brazil. The Framingham score ≥10 was similar between regions for males, patients aged ≥60 years, with obesity, central obesity, hypertension, and diabetes mellitus. Women were three times more likely to have coronary heart disease in 10 years than men. Hypertension and diabetes increased more than four times the risk of coronary heart disease, followed by central obesity, obesity, and prehypertension. The use of antiretroviral agents and time since HIV diagnosis were not risk factors for coronary artery disease in 10 years. In conclusion, hypertension and diabetes are the strongest independent predictors of 10-year risk of coronary heart disease among HIV-infected population.http://dx.doi.org/10.1155/2013/163418 |
| spellingShingle | Sandra C. Fuchs Paulo R. Alencastro Maria Letícia R. Ikeda Nêmora T. Barcellos Fernando H. Wolff Ajácio B. M. Brandão Ricardo A. A. Ximenes Demócrito de B. Miranda-Filho Heloísa Ramos Lacerda Maria de Fátima P. M. de Albuquerque Ulisses Ramos Montarroyos Max W. Nery Marilia D. Turchi Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil The Scientific World Journal |
| title | Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil |
| title_full | Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil |
| title_fullStr | Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil |
| title_full_unstemmed | Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil |
| title_short | Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil |
| title_sort | risk of coronary heart disease among hiv infected patients a multicenter study in brazil |
| url | http://dx.doi.org/10.1155/2013/163418 |
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