Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy
Immune modulation at the fetomaternal interface is crucial to ensure that the fetal allograft is not rejected. In the present review, the focus is to describe basic functions of lymphocyte populations and how they may contribute to fetomaternal immune regulation, as well as determining what proporti...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/5738371 |
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| _version_ | 1832555118251212800 |
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| author | Tom Erkers Arwen Stikvoort Michael Uhlin |
| author_facet | Tom Erkers Arwen Stikvoort Michael Uhlin |
| author_sort | Tom Erkers |
| collection | DOAJ |
| description | Immune modulation at the fetomaternal interface is crucial to ensure that the fetal allograft is not rejected. In the present review, the focus is to describe basic functions of lymphocyte populations and how they may contribute to fetomaternal immune regulation, as well as determining what proportions and effector functions of these cells are reported to be present in placental tissues in humans. Also explored is the possibility that unique cell populations at the fetomaternal interface may be targets for adoptive cell therapy. Increasing the understanding of immune modulation during pregnancy can give valuable insight into other established fields such as allogeneic hematopoietic stem cell transplantation and solid organ transplantation. In these settings, lymphocytes are key components that contribute to inflammation and rejection of either patient or donor tissues following transplantation. In contrast, an allogeneic fetus eludes rejection by the maternal immune system. |
| format | Article |
| id | doaj-art-9059d28b2282401995e7afd3dbd1a89d |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9059d28b2282401995e7afd3dbd1a89d2025-02-03T05:49:36ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/57383715738371Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for ImmunotherapyTom Erkers0Arwen Stikvoort1Michael Uhlin2Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USADepartment of Oncology-Pathology, Karolinska University Hospital Huddinge, Stockholm, SwedenDepartment of Clinical Immunology and Transfusion Medicine (KITM), Karolinska University Hospital Huddinge, Stockholm, SwedenImmune modulation at the fetomaternal interface is crucial to ensure that the fetal allograft is not rejected. In the present review, the focus is to describe basic functions of lymphocyte populations and how they may contribute to fetomaternal immune regulation, as well as determining what proportions and effector functions of these cells are reported to be present in placental tissues in humans. Also explored is the possibility that unique cell populations at the fetomaternal interface may be targets for adoptive cell therapy. Increasing the understanding of immune modulation during pregnancy can give valuable insight into other established fields such as allogeneic hematopoietic stem cell transplantation and solid organ transplantation. In these settings, lymphocytes are key components that contribute to inflammation and rejection of either patient or donor tissues following transplantation. In contrast, an allogeneic fetus eludes rejection by the maternal immune system.http://dx.doi.org/10.1155/2017/5738371 |
| spellingShingle | Tom Erkers Arwen Stikvoort Michael Uhlin Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy Stem Cells International |
| title | Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy |
| title_full | Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy |
| title_fullStr | Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy |
| title_full_unstemmed | Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy |
| title_short | Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy |
| title_sort | lymphocytes in placental tissues immune regulation and translational possibilities for immunotherapy |
| url | http://dx.doi.org/10.1155/2017/5738371 |
| work_keys_str_mv | AT tomerkers lymphocytesinplacentaltissuesimmuneregulationandtranslationalpossibilitiesforimmunotherapy AT arwenstikvoort lymphocytesinplacentaltissuesimmuneregulationandtranslationalpossibilitiesforimmunotherapy AT michaeluhlin lymphocytesinplacentaltissuesimmuneregulationandtranslationalpossibilitiesforimmunotherapy |