Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus
Subplantar injection of Pilocarpus spicatus essential oil (PSEO), induced rat hindpaw oedema in a dose-dependent manner. The time course study revealed that when compared to carrageenan-induced oedema, the oedema response to PSEO was greater at 1 h post-injection, and thereafter remained relatively...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000255 |
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| author | J. C. R. Silva V. S. N. Rao |
| author_facet | J. C. R. Silva V. S. N. Rao |
| author_sort | J. C. R. Silva |
| collection | DOAJ |
| description | Subplantar injection of Pilocarpus spicatus essential oil (PSEO), induced rat hindpaw oedema in a dose-dependent manner. The time course study revealed that when compared to carrageenan-induced oedema, the oedema response to PSEO was greater at 1 h post-injection, and thereafter remained relatively constant until 5 h post-injection. By 24 h, it was still at almost the 50% level. This effect of PSEO was characterized using several inhibitors of oedema formation. Pretreatment with the H1-receptor antagonist chlorpheniramine did not affect this response, while a significant reduction of paw oedema was achieved with the serotonin antagonist methysergide, but only 1 h and 2 h after injection of PSEO. The oedemagenic activity of PSEO was also suppressed by pretreating the rats with the eicosanoid synthesis inhibitors, phenylbutazone, EP 10161 and dexamethasone. This last drug showed the greatest potency. These findings suggested a probable injury to dermal mast cells and liberation of arachidonate metabolites and eicosanoids at the late phase of oedema induced by PSEO. |
| format | Article |
| id | doaj-art-8fe37b44174642a99f559b1db098260c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8fe37b44174642a99f559b1db098260c2025-02-03T05:58:46ZengWileyMediators of Inflammation0962-93511466-18611992-01-011316716910.1155/S0962935192000255Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatusJ. C. R. Silva0V. S. N. Rao1Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal do Cearfi. Caixa Postal–657., Fortaleza, CE 60.O00, BrazilDepartamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal do Cearfi. Caixa Postal–657., Fortaleza, CE 60.O00, BrazilSubplantar injection of Pilocarpus spicatus essential oil (PSEO), induced rat hindpaw oedema in a dose-dependent manner. The time course study revealed that when compared to carrageenan-induced oedema, the oedema response to PSEO was greater at 1 h post-injection, and thereafter remained relatively constant until 5 h post-injection. By 24 h, it was still at almost the 50% level. This effect of PSEO was characterized using several inhibitors of oedema formation. Pretreatment with the H1-receptor antagonist chlorpheniramine did not affect this response, while a significant reduction of paw oedema was achieved with the serotonin antagonist methysergide, but only 1 h and 2 h after injection of PSEO. The oedemagenic activity of PSEO was also suppressed by pretreating the rats with the eicosanoid synthesis inhibitors, phenylbutazone, EP 10161 and dexamethasone. This last drug showed the greatest potency. These findings suggested a probable injury to dermal mast cells and liberation of arachidonate metabolites and eicosanoids at the late phase of oedema induced by PSEO.http://dx.doi.org/10.1155/S0962935192000255 |
| spellingShingle | J. C. R. Silva V. S. N. Rao Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus Mediators of Inflammation |
| title | Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus |
| title_full | Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus |
| title_fullStr | Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus |
| title_full_unstemmed | Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus |
| title_short | Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus |
| title_sort | involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of pilocarpus spicatus |
| url | http://dx.doi.org/10.1155/S0962935192000255 |
| work_keys_str_mv | AT jcrsilva involvementofserotoninandeicosanoidsintheratpawoedemaresponsetotheessentialoilofpilocarpusspicatus AT vsnrao involvementofserotoninandeicosanoidsintheratpawoedemaresponsetotheessentialoilofpilocarpusspicatus |