Certain pMMR colorectal cancer patients should undergo additional MSI-PCR testing to reduce the risk of misdiagnosing MSI-H and Lynch syndrome

Certain pMMR colorectal cancer patients should undergo additional MSI-PCR testing to reduce the risk of misdiagnosing MSI-H and Lynch syndrome

Abstract Background Microsatellite instability (MSI) status guides immunotherapy and Lynch syndrome (LS) screening. Given the 5–10% discordance rate between mismatch repair immunohistochemistry (MMR-IHC) and Microsatellite instability polymerase chain reaction (MSI-PCR), true high microsatellite ins...

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Bibliographic Details
Main Authors: Jinglin Huang, Liang Xu, Yacheng Cai, Xiaoli Tan, Hanjie Lin, Zhiting Chen, Chao Wang, Weihao Deng, Xinhui Fu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
MMR-IHC
MSI-PCR
Colorectal cancer
PMMR
MSI-H
Lynch syndrome
Online Access:https://doi.org/10.1186/s12885-025-14484-3
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https://doi.org/10.1186/s12885-025-14484-3

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