Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up
Background. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal struc...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2021/5573839 |
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| author | Riwanti Estiasari Adisresti Diwyacitta Muhammad Sidik Ni Nengah Rida Ariarini Freddy Sitorus Saraf Shafa Marwadhani Kartika Maharani Darma Imran Reza Aditya Arpandy David Pangeran Manfaluthy Hakim |
| author_facet | Riwanti Estiasari Adisresti Diwyacitta Muhammad Sidik Ni Nengah Rida Ariarini Freddy Sitorus Saraf Shafa Marwadhani Kartika Maharani Darma Imran Reza Aditya Arpandy David Pangeran Manfaluthy Hakim |
| author_sort | Riwanti Estiasari |
| collection | DOAJ |
| description | Background. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes. Methods. This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography. Results. The MS group had lower BCVA (p=0.001), contrast sensitivity (p<0.001), mean GCIPL thickness (p<0.001), and mean RNFL thickness (p<0.001) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly (p=0.007 and p=0.004, respectively). Disease duration and the number of relapses correlated with delayed P100 latency (r = −0.61, p<0.001 and r = −0.46, p=0.02). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS. Conclusions. The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability. |
| format | Article |
| id | doaj-art-8f94606da8e74c8697d89dbd127c7e57 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-8f94606da8e74c8697d89dbd127c7e572025-02-03T01:00:48ZengWileyNeurology Research International2090-18522090-18602021-01-01202110.1155/2021/55738395573839Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-UpRiwanti Estiasari0Adisresti Diwyacitta1Muhammad Sidik2Ni Nengah Rida Ariarini3Freddy Sitorus4Saraf Shafa Marwadhani5Kartika Maharani6Darma Imran7Reza Aditya Arpandy8David Pangeran9Manfaluthy Hakim10Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, IndonesiaBackground. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes. Methods. This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography. Results. The MS group had lower BCVA (p=0.001), contrast sensitivity (p<0.001), mean GCIPL thickness (p<0.001), and mean RNFL thickness (p<0.001) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly (p=0.007 and p=0.004, respectively). Disease duration and the number of relapses correlated with delayed P100 latency (r = −0.61, p<0.001 and r = −0.46, p=0.02). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS. Conclusions. The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability.http://dx.doi.org/10.1155/2021/5573839 |
| spellingShingle | Riwanti Estiasari Adisresti Diwyacitta Muhammad Sidik Ni Nengah Rida Ariarini Freddy Sitorus Saraf Shafa Marwadhani Kartika Maharani Darma Imran Reza Aditya Arpandy David Pangeran Manfaluthy Hakim Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up Neurology Research International |
| title | Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
| title_full | Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
| title_fullStr | Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
| title_full_unstemmed | Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
| title_short | Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
| title_sort | evaluation of retinal structure and optic nerve function changes in multiple sclerosis longitudinal study with 1 year follow up |
| url | http://dx.doi.org/10.1155/2021/5573839 |
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