Characterization of Immunoglobulin Heavy Locus Rearrangements in Molecular Subtypes of Childhood B‐Cell Precursor Acute Lymphoblastic Leukemia

Characterization of Immunoglobulin Heavy Locus Rearrangements in Molecular Subtypes of Childhood B‐Cell Precursor Acute Lymphoblastic Leukemia

ABSTRACT Biased IGH VDJ recombination has been previously described in childhood B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), although its causes are not yet fully understood. This study assesses differential features in 565 IGH clonotypes from BCP‐ALL molecular subsets against 560 clono...

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Main Authors: Guilherme Navarro Nilo Giusti, Patrícia Yoshioka Jotta, Caroline deOliveira Lopes, Natacha Azussa Migita, Amilcar Cardoso deAzevedo, Sílvia Regina Brandalise, João Meidanis, José Andrés Yunes
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:eJHaem
Subjects:
acute lymphoblastic leukemia
ETV6‐RUNX1
immunoglobulin heavy locus
minimal residual disease
VDJ recombination
Online Access:https://doi.org/10.1002/jha2.70003
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https://doi.org/10.1002/jha2.70003

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