Epigenetic changes and serotype-specific responses of alveolar type II epithelial cells to Streptococcus pneumoniae in resolving influenza A virus infection

Abstract Background Pneumococcal pneumonia following influenza A virus (IAV) infection is a synergistic complication with high mortality in which IAV infection modulates host antibacterial responses and affects bacterial invasiveness of Streptococcus pneumoniae (S. pn.). IAV-mediated effects can las...

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Bibliographic Details
Main Authors:	Julia D Boehme, Andreas Jeron, Kristin Schultz, Lars Melcher, Katharina Schott, Elif Gelmez, Andrea Kröger, Sabine Stegemann-Koniszewski, Dunja Bruder
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Series:	Cell Communication and Signaling
Subjects:	Influenza A virus Streptococcus pneumoniae Alveolar type II epithelial cells Interferon response Secondary infection Gene co-expression network
Online Access:	https://doi.org/10.1186/s12964-025-02284-y
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Epigenetic changes and serotype-specific responses of alveolar type II epithelial cells to Streptococcus pneumoniae in resolving influenza A virus infection

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