Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of China
Objective. The main aim of this study was to determine the prevalence, capsular genotyping, antimicrobial susceptibility, and associated factors of colonizing Group B Streptococcus (GBS) in pregnant women admitted to a hospital in Jinan, East China. Methods. Demographic data, clinical characteristic...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/5236430 |
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| _version_ | 1832566906425442304 |
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| author | Jin Jiao Weiwei Wu Feng Shen Zhongyuan Liu Huiru Zhou Gang Fan Yuxia Zhou |
| author_facet | Jin Jiao Weiwei Wu Feng Shen Zhongyuan Liu Huiru Zhou Gang Fan Yuxia Zhou |
| author_sort | Jin Jiao |
| collection | DOAJ |
| description | Objective. The main aim of this study was to determine the prevalence, capsular genotyping, antimicrobial susceptibility, and associated factors of colonizing Group B Streptococcus (GBS) in pregnant women admitted to a hospital in Jinan, East China. Methods. Demographic data, clinical characteristics, and vaginal and rectal swabs were obtained from a group of expecting mothers subjected to GBS screening at the late stage of pregnancy who went into labor over the period from November 2019 to October 2020. Identification of GBS and determination of antimicrobial resistance patterns were performed using a BD Phoenix-100 system. Capsular genotypes were analyzed using polymerase chain reaction and the associated factors were evaluated via logistic regression. Result. A total of 2761 pregnant women were recruited for this study. The GBS colonization rate was 6.70% (185/2761). Among the 172 GBS strains examined, all were susceptible to vancomycin and linezolid. Resistance was the highest for erythromycin (80.2%), followed by clindamycin (75.0%), levofloxacin (65.1%), and tetracycline (57.6%). The most common serotype identified was Ia (61.0%), followed by III (29.7%), VI (4.6%), II (3.5%), VII (0.6%), and a nontypeable strain. Risk factors for maternal GBS colonization included maternal age (older than 30 years) (OR = 1.913 (1.662, 2.478)), gestational age at birth (average gestational age) (OR = 1.992 (1.445, 2.746)), and prelabor rupture of membrane (OR = 3.838 (1.619, 9.099)). Conclusion. The prevalence of GBS was relatively low. The maternal age was a factor associated with GBS colonization. Subjects showing GBS positivity during late pregnancy were prone to prolonged rupture of the membrane (PROM) and birth at lower a gestation age than the GBS-negative group. Penicillin could still be used as the first agent of choice for intrapartum antibiotic prophylaxis (IAP). |
| format | Article |
| id | doaj-art-8f86561668e74ad9aa0a29d9ffc6eaa5 |
| institution | Kabale University |
| issn | 1687-9694 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-8f86561668e74ad9aa0a29d9ffc6eaa52025-02-03T01:02:53ZengWileyJournal of Tropical Medicine1687-96942022-01-01202210.1155/2022/5236430Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of ChinaJin Jiao0Weiwei Wu1Feng Shen2Zhongyuan Liu3Huiru Zhou4Gang Fan5Yuxia Zhou6Department of Clinical LaboratoryDepartment of Clinical LaboratoryDepartment of Clinical LaboratoryDepartment of Clinical LaboratoryDepartment of Clinical LaboratoryDepartment of Clinical LaboratoryDepartment of Clinical LaboratoryObjective. The main aim of this study was to determine the prevalence, capsular genotyping, antimicrobial susceptibility, and associated factors of colonizing Group B Streptococcus (GBS) in pregnant women admitted to a hospital in Jinan, East China. Methods. Demographic data, clinical characteristics, and vaginal and rectal swabs were obtained from a group of expecting mothers subjected to GBS screening at the late stage of pregnancy who went into labor over the period from November 2019 to October 2020. Identification of GBS and determination of antimicrobial resistance patterns were performed using a BD Phoenix-100 system. Capsular genotypes were analyzed using polymerase chain reaction and the associated factors were evaluated via logistic regression. Result. A total of 2761 pregnant women were recruited for this study. The GBS colonization rate was 6.70% (185/2761). Among the 172 GBS strains examined, all were susceptible to vancomycin and linezolid. Resistance was the highest for erythromycin (80.2%), followed by clindamycin (75.0%), levofloxacin (65.1%), and tetracycline (57.6%). The most common serotype identified was Ia (61.0%), followed by III (29.7%), VI (4.6%), II (3.5%), VII (0.6%), and a nontypeable strain. Risk factors for maternal GBS colonization included maternal age (older than 30 years) (OR = 1.913 (1.662, 2.478)), gestational age at birth (average gestational age) (OR = 1.992 (1.445, 2.746)), and prelabor rupture of membrane (OR = 3.838 (1.619, 9.099)). Conclusion. The prevalence of GBS was relatively low. The maternal age was a factor associated with GBS colonization. Subjects showing GBS positivity during late pregnancy were prone to prolonged rupture of the membrane (PROM) and birth at lower a gestation age than the GBS-negative group. Penicillin could still be used as the first agent of choice for intrapartum antibiotic prophylaxis (IAP).http://dx.doi.org/10.1155/2022/5236430 |
| spellingShingle | Jin Jiao Weiwei Wu Feng Shen Zhongyuan Liu Huiru Zhou Gang Fan Yuxia Zhou Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of China Journal of Tropical Medicine |
| title | Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of China |
| title_full | Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of China |
| title_fullStr | Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of China |
| title_full_unstemmed | Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of China |
| title_short | Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of China |
| title_sort | clinical profile and risk factors of group b streptococcal colonization in mothers from the eastern district of china |
| url | http://dx.doi.org/10.1155/2022/5236430 |
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