Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumoursResearch in context

Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumoursResearch in context

Summary: Background: Primary cutaneous melanocytic tumours harbouring MAP2K1 mutations without second-hit genomic alterations represent a subclass of neoplasms with poorly understood biological behaviour. This study aimed to investigate the clinical outcomes and genomic characteristics of these tum...

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Main Authors: Chiel F. Ebbelaar, Anne M.L. Jansen, Leonie C.M. Speet, Frans Schutgens, Sietske Zoetemeyer, Anne-Marie Cleton-Jansen, Marijke R. van Dijk, Gerben E. Breimer, Lourens T. Bloem, Wendy W.J. de Leng, Remco van Doorn, Karijn P.M. Suijkerbuijk, Anne M.R. Schrader, Willeke A.M. Blokx
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:EBioMedicine
Subjects:
MAP2K1 mutations
Melanoma
Prognosis
Metastasis
Molecular oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425000878
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http://www.sciencedirect.com/science/article/pii/S2352396425000878

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