Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches
A new HPLC method was introduced and validated for simultaneous determination of perindopril and indapamide. Validation procedure included specificity, sensitivity, robustness, stability, linearity, precision and accuracy. The method was used for the dissolution test of perindopril and indapamide in...
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| Format: | Article |
| Language: | English |
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Sciendo
2015-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2015-0024 |
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| _version_ | 1832572082924290048 |
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| author | Gumieniczek Anna Mączka Paulina Komsta Łukasz Pietraś Rafał |
| author_facet | Gumieniczek Anna Mączka Paulina Komsta Łukasz Pietraś Rafał |
| author_sort | Gumieniczek Anna |
| collection | DOAJ |
| description | A new HPLC method was introduced and validated for simultaneous determination of perindopril and indapamide. Validation procedure included specificity, sensitivity, robustness, stability, linearity, precision and accuracy. The method was used for the dissolution test of perindopril and indapamide in three fixed-dose formulations. The dissolution procedure was optimized using different media, different pH of the buffer, surfactants, paddle speed and temperature. Similarity of dissolution profiles was estimated using different model-independent and model-dependent methods and, additionally, by principal component analysis (PCA). Also, some kinetic models were checked for dissolved amounts of drugs as a function of time. |
| format | Article |
| id | doaj-art-8f51e2ac82e54b16b86b7416949c8322 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-8f51e2ac82e54b16b86b7416949c83222025-02-02T11:55:55ZengSciendoActa Pharmaceutica1846-95582015-09-0165323525210.1515/acph-2015-0024acph-2015-0024Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approachesGumieniczek Anna0Mączka Paulina1Komsta Łukasz2Pietraś Rafał3Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University in Lublin, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University in Lublin, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University in Lublin, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University in Lublin, 20-090 Lublin, PolandA new HPLC method was introduced and validated for simultaneous determination of perindopril and indapamide. Validation procedure included specificity, sensitivity, robustness, stability, linearity, precision and accuracy. The method was used for the dissolution test of perindopril and indapamide in three fixed-dose formulations. The dissolution procedure was optimized using different media, different pH of the buffer, surfactants, paddle speed and temperature. Similarity of dissolution profiles was estimated using different model-independent and model-dependent methods and, additionally, by principal component analysis (PCA). Also, some kinetic models were checked for dissolved amounts of drugs as a function of time.https://doi.org/10.1515/acph-2015-0024perindoprilindapamidedissolution profilesmodel-independent methodsmodel-dependent methodspca |
| spellingShingle | Gumieniczek Anna Mączka Paulina Komsta Łukasz Pietraś Rafał Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches Acta Pharmaceutica perindopril indapamide dissolution profiles model-independent methods model-dependent methods pca |
| title | Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches |
| title_full | Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches |
| title_fullStr | Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches |
| title_full_unstemmed | Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches |
| title_short | Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches |
| title_sort | dissolution profiles of perindopril and indapamide in their fixed dose formulations by a new hplc method and different mathematical approaches |
| topic | perindopril indapamide dissolution profiles model-independent methods model-dependent methods pca |
| url | https://doi.org/10.1515/acph-2015-0024 |
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