Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia
Abstract The kidneys are essential for glucose homeostasis, as they perform gluconeogenesis, utilize glucose, and reabsorb glucose. Reabsorption is performed by SGLT2, which is responsible for about 90%. However, little is known about how renal glucose handling is altered in patients with chronic ki...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70121 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586733788594176 |
|---|---|
| author | Yuri Sakai Ishizaki Masao Kikuchi Koichi Kaikita Shouichi Fujimoto |
| author_facet | Yuri Sakai Ishizaki Masao Kikuchi Koichi Kaikita Shouichi Fujimoto |
| author_sort | Yuri Sakai Ishizaki |
| collection | DOAJ |
| description | Abstract The kidneys are essential for glucose homeostasis, as they perform gluconeogenesis, utilize glucose, and reabsorb glucose. Reabsorption is performed by SGLT2, which is responsible for about 90%. However, little is known about how renal glucose handling is altered in patients with chronic kidney disease (CKD). SGLT2 inhibitors have demonstrated efficacy in suppressing CKD progression in clinical trials, but their mechanisms are not fully understood. Therefore, this study aimed to evaluate how each uninephrectomy (UNx) and SGLT2 inhibitor affects blood glucose concentrations and SGLTs dynamics in rats with type 2 diabetes mellitus. Male rats were divided into four treatment groups: sham + placebo, sham + dapagliflozin, UNx + placebo, and UNx + dapagliflozin. There were few group differences in food intake or body weight, but blood glucose concentrations continued to rise in the sham + placebo, whereas this rise was delayed for several weeks in the UNx + placebo, and largely suppressed by dapagliflozin. SGLT2 mRNA expression was significantly lower in the UNx group, but SGLT1 mRNA expression did not significantly differ. Dapagliflozin did not alter SGLT1 or SGLT2 mRNA expression. In animal models of diabetes, renal glucose reabsorption appears likely to be a major contributor to the development of hyperglycemia. |
| format | Article |
| id | doaj-art-8f17f8aa32d24ec1b0332408e0dbd87d |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-8f17f8aa32d24ec1b0332408e0dbd87d2025-01-25T06:41:00ZengWileyPhysiological Reports2051-817X2024-11-011221n/an/a10.14814/phy2.70121Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemiaYuri Sakai Ishizaki0Masao Kikuchi1Koichi Kaikita2Shouichi Fujimoto3Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki Miyazaki JapanDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki Miyazaki JapanDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki Miyazaki JapanDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki Miyazaki JapanAbstract The kidneys are essential for glucose homeostasis, as they perform gluconeogenesis, utilize glucose, and reabsorb glucose. Reabsorption is performed by SGLT2, which is responsible for about 90%. However, little is known about how renal glucose handling is altered in patients with chronic kidney disease (CKD). SGLT2 inhibitors have demonstrated efficacy in suppressing CKD progression in clinical trials, but their mechanisms are not fully understood. Therefore, this study aimed to evaluate how each uninephrectomy (UNx) and SGLT2 inhibitor affects blood glucose concentrations and SGLTs dynamics in rats with type 2 diabetes mellitus. Male rats were divided into four treatment groups: sham + placebo, sham + dapagliflozin, UNx + placebo, and UNx + dapagliflozin. There were few group differences in food intake or body weight, but blood glucose concentrations continued to rise in the sham + placebo, whereas this rise was delayed for several weeks in the UNx + placebo, and largely suppressed by dapagliflozin. SGLT2 mRNA expression was significantly lower in the UNx group, but SGLT1 mRNA expression did not significantly differ. Dapagliflozin did not alter SGLT1 or SGLT2 mRNA expression. In animal models of diabetes, renal glucose reabsorption appears likely to be a major contributor to the development of hyperglycemia.https://doi.org/10.14814/phy2.70121chronic kidney diseasediabetesglucose homeostasisglucose reabsorptionsodium‐glucose cotransporters |
| spellingShingle | Yuri Sakai Ishizaki Masao Kikuchi Koichi Kaikita Shouichi Fujimoto Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia Physiological Reports chronic kidney disease diabetes glucose homeostasis glucose reabsorption sodium‐glucose cotransporters |
| title | Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia |
| title_full | Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia |
| title_fullStr | Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia |
| title_full_unstemmed | Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia |
| title_short | Uninephrectomy and sodium‐glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia |
| title_sort | uninephrectomy and sodium glucose cotransporter 2 inhibitor administration delay the onset of hyperglycemia |
| topic | chronic kidney disease diabetes glucose homeostasis glucose reabsorption sodium‐glucose cotransporters |
| url | https://doi.org/10.14814/phy2.70121 |
| work_keys_str_mv | AT yurisakaiishizaki uninephrectomyandsodiumglucosecotransporter2inhibitoradministrationdelaytheonsetofhyperglycemia AT masaokikuchi uninephrectomyandsodiumglucosecotransporter2inhibitoradministrationdelaytheonsetofhyperglycemia AT koichikaikita uninephrectomyandsodiumglucosecotransporter2inhibitoradministrationdelaytheonsetofhyperglycemia AT shouichifujimoto uninephrectomyandsodiumglucosecotransporter2inhibitoradministrationdelaytheonsetofhyperglycemia |