Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways
In all vertebrate species, estrogens play a crucial role in the development, growth, and function of reproductive and nonreproductive tissues. A large number of natural or synthetic chemicals present in the environment and diet can interfere with estrogen signaling; these chemicals are called endocr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/501851 |
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| author | Gwenneg Kerdivel Denis Habauzit Farzad Pakdel |
| author_facet | Gwenneg Kerdivel Denis Habauzit Farzad Pakdel |
| author_sort | Gwenneg Kerdivel |
| collection | DOAJ |
| description | In all vertebrate species, estrogens play a crucial role in the development, growth, and function of reproductive and nonreproductive tissues. A large number of natural or synthetic chemicals present in the environment and diet can interfere with estrogen signaling; these chemicals are called endocrine disrupting chemicals (EDCs) or xenoestrogens. Some of these compounds have been shown to induce adverse effects on human and animal health, and some compounds are suspected to contribute to diverse disease development. Because xenoestrogens have varying sources and structures and could act in additive or synergistic effects when combined, they have multiple mechanisms of action. Consequently, an important panel of in vivo and in vitro bioassays and chemical analytical tools was used to screen, evaluate, and characterize the potential impacts of these compounds on humans and animals. In this paper, we discuss different molecular actions of some of the major xenoestrogens found in food or the environment, and we summarize the current models used to evaluate environmental estrogens. |
| format | Article |
| id | doaj-art-8ee41c780fa34c92a7c98c5d5fab050b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8ee41c780fa34c92a7c98c5d5fab050b2025-02-03T06:06:03ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/501851501851Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor PathwaysGwenneg Kerdivel0Denis Habauzit1Farzad Pakdel2Institut de Recherche en Santé Environnement Travail (IRSET), INSERM U1085, TREC Team, SFR Biosit, University of Rennes 1, 35042 Rennes Cedex, FranceInstitut de Recherche en Santé Environnement Travail (IRSET), INSERM U1085, TREC Team, SFR Biosit, University of Rennes 1, 35042 Rennes Cedex, FranceInstitut de Recherche en Santé Environnement Travail (IRSET), INSERM U1085, TREC Team, SFR Biosit, University of Rennes 1, 35042 Rennes Cedex, FranceIn all vertebrate species, estrogens play a crucial role in the development, growth, and function of reproductive and nonreproductive tissues. A large number of natural or synthetic chemicals present in the environment and diet can interfere with estrogen signaling; these chemicals are called endocrine disrupting chemicals (EDCs) or xenoestrogens. Some of these compounds have been shown to induce adverse effects on human and animal health, and some compounds are suspected to contribute to diverse disease development. Because xenoestrogens have varying sources and structures and could act in additive or synergistic effects when combined, they have multiple mechanisms of action. Consequently, an important panel of in vivo and in vitro bioassays and chemical analytical tools was used to screen, evaluate, and characterize the potential impacts of these compounds on humans and animals. In this paper, we discuss different molecular actions of some of the major xenoestrogens found in food or the environment, and we summarize the current models used to evaluate environmental estrogens.http://dx.doi.org/10.1155/2013/501851 |
| spellingShingle | Gwenneg Kerdivel Denis Habauzit Farzad Pakdel Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways International Journal of Endocrinology |
| title | Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways |
| title_full | Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways |
| title_fullStr | Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways |
| title_full_unstemmed | Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways |
| title_short | Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways |
| title_sort | assessment and molecular actions of endocrine disrupting chemicals that interfere with estrogen receptor pathways |
| url | http://dx.doi.org/10.1155/2013/501851 |
| work_keys_str_mv | AT gwennegkerdivel assessmentandmolecularactionsofendocrinedisruptingchemicalsthatinterferewithestrogenreceptorpathways AT denishabauzit assessmentandmolecularactionsofendocrinedisruptingchemicalsthatinterferewithestrogenreceptorpathways AT farzadpakdel assessmentandmolecularactionsofendocrinedisruptingchemicalsthatinterferewithestrogenreceptorpathways |