Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy

Abstract Background Exposure to repetitive head impacts (RHI) is associated with increased risk for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, and other neuropathological changes. Biological drivers of RHI-related neurodegeneration are not well understood. We interrogated...

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Main Authors: Rowan Saloner, Kaitlin B. Casaletto, Sruti Rayaprolu, Louisa Cornelis, Paramita Chakrabarty, Jose F. Abisambra, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Joel H. Kramer, Gil D. Rabinovici, Breton M. Asken
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Neurodegeneration
Subjects:
Repetitive head impacts
Chronic traumatic encephalopathy
Traumatic brain injury
Plasma proteomics
Mixed neuropathology
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13024-025-00860-x
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https://doi.org/10.1186/s13024-025-00860-x

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