Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study
Tuberculosis (TB) remains a significant global health challenge, with the World Health Organization (WHO) aiming for a 95% reduction in TB deaths by 2030. Disparities in TB detection persist, particularly regarding gender, immigration status, and resistance patterns. In Calabria, Italy—a key entry p...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405579425000038 |
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| author | Salvatore Rotundo Salvatore Nisticò Helen Linda Morrone Luigia Gallo Saveria Dodaro Carmelo Papola Pasquale Minchella Giovanni Matera Francesca Greco Luigi Principe Lorenzo Antonio Surace Francesco Lucia Francesca Serapide Alessandro Russo Carlo Torti Enrico Maria Trecarichi |
| author_facet | Salvatore Rotundo Salvatore Nisticò Helen Linda Morrone Luigia Gallo Saveria Dodaro Carmelo Papola Pasquale Minchella Giovanni Matera Francesca Greco Luigi Principe Lorenzo Antonio Surace Francesco Lucia Francesca Serapide Alessandro Russo Carlo Torti Enrico Maria Trecarichi |
| author_sort | Salvatore Rotundo |
| collection | DOAJ |
| description | Tuberculosis (TB) remains a significant global health challenge, with the World Health Organization (WHO) aiming for a 95% reduction in TB deaths by 2030. Disparities in TB detection persist, particularly regarding gender, immigration status, and resistance patterns. In Calabria, Italy—a key entry point for migrants from high-TB-incidence regions—TB poses a notable public health risk. This multicenter, retrospective study examines newly diagnosed TB cases in Calabria from 2012 to 2023, focusing on rifampicin-resistant TB (RR-TB).During this period, 800 TB cases were diagnosed, with 270 (33.7 %) in native-born Italians and 530 (66.2 %) in foreign-born individuals, showing significant differences in age (p < 0.001) and gender (p = 0.013). Among 685 patients of this cohort with available HIV status, 24 (3.5 %) were people living with HIV (PLWH), primarily from Africa, and diagnosed at higher rates of RR-TB (p < 0.001). TB cases varied by province, correlating with specific birthplaces. A total of 27 (3.4 %) RR-TB cases were identified, with heightened resistance to multiple drugs. Among these strains, 20 (74.1 %) were isoniazid-resistant (MDR-TB).This study underscores the need for comprehensive TB control strategies, especially regarding co-infection with HIV and the emergence of drug-resistant strains, emphasizing the importance of early detection and tailored management in Southern Italy. |
| format | Article |
| id | doaj-art-8eb80fda6cb845d4b792562d95d0dd4e |
| institution | Kabale University |
| issn | 2405-5794 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| spelling | doaj-art-8eb80fda6cb845d4b792562d95d0dd4e2025-01-31T05:11:55ZengElsevierJournal of Clinical Tuberculosis and Other Mycobacterial Diseases2405-57942025-02-0138100512Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based studySalvatore Rotundo0Salvatore Nisticò1Helen Linda Morrone2Luigia Gallo3Saveria Dodaro4Carmelo Papola5Pasquale Minchella6Giovanni Matera7Francesca Greco8Luigi Principe9Lorenzo Antonio Surace10Francesco Lucia11Francesca Serapide12Alessandro Russo13Carlo Torti14Enrico Maria Trecarichi15Department of Medical and Surgical Sciences, “Magna Graecia” University, 88100 Catanzaro, Italy; Corresponding author.Clinical Microbiology Unit, “Renato Dulbecco” University Hospital, “Mater Domini” Medical Center, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, “Magna Graecia” University, 88100 Catanzaro, ItalyClinical Microbiology Unit, “Renato Dulbecco” University Hospital, “Mater Domini” Medical Center, Catanzaro, ItalyMicrobiology and Virology Unit, “Annunziata” Hospital, Cosenza, ItalyClinical Microbiology and Virology Unit, Great Metropolitan Hospital “Bianchi-Melacrino-Morelli”, Reggio Calabria, ItalyMicrobiology and Virology Unit, “Renato Dulbecco” University Hospital, “Pugliese-Ciaccio” Medical Center, Catanzaro, ItalyClinical Microbiology Unit, “Renato Dulbecco” University Hospital, “Mater Domini” Medical Center, Catanzaro, Italy; Department of Health Sciences, “Magna Graecia” University, Catanzaro, ItalyMicrobiology and Virology Unit, “Annunziata” Hospital, Cosenza, ItalyClinical Microbiology and Virology Unit, Great Metropolitan Hospital “Bianchi-Melacrino-Morelli”, Reggio Calabria, ItalyCenter for Travel and Migration Medicine, Provincial Health Authority of Catanzaro, Lamezia Terme, ItalyDepartment of Health Protection and Social Health Services, Sector of Prevention and Public Health, Regional Council of Calabria, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, “Magna Graecia” University, 88100 Catanzaro, Italy; Infectious and Tropical Disease Unit, “Renato Dulbecco” University Hospital, “Mater Domini” Medical Center, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, “Magna Graecia” University, 88100 Catanzaro, Italy; Infectious and Tropical Disease Unit, “Renato Dulbecco” University Hospital, “Mater Domini” Medical Center, Catanzaro, ItalyDepartment of Safety and Bioethics, Catholic University of the Sacred Heart, Rome, Italy; Infectious Diseases Unit, “Agostino Gemelli” University Hospital, Rome, ItalyDepartment of Medical and Surgical Sciences, “Magna Graecia” University, 88100 Catanzaro, Italy; Infectious and Tropical Disease Unit, “Renato Dulbecco” University Hospital, “Mater Domini” Medical Center, Catanzaro, Italy; Department of Life Sciences, Health and Healthcare Professions, Link Campus University, Rome, ItalyTuberculosis (TB) remains a significant global health challenge, with the World Health Organization (WHO) aiming for a 95% reduction in TB deaths by 2030. Disparities in TB detection persist, particularly regarding gender, immigration status, and resistance patterns. In Calabria, Italy—a key entry point for migrants from high-TB-incidence regions—TB poses a notable public health risk. This multicenter, retrospective study examines newly diagnosed TB cases in Calabria from 2012 to 2023, focusing on rifampicin-resistant TB (RR-TB).During this period, 800 TB cases were diagnosed, with 270 (33.7 %) in native-born Italians and 530 (66.2 %) in foreign-born individuals, showing significant differences in age (p < 0.001) and gender (p = 0.013). Among 685 patients of this cohort with available HIV status, 24 (3.5 %) were people living with HIV (PLWH), primarily from Africa, and diagnosed at higher rates of RR-TB (p < 0.001). TB cases varied by province, correlating with specific birthplaces. A total of 27 (3.4 %) RR-TB cases were identified, with heightened resistance to multiple drugs. Among these strains, 20 (74.1 %) were isoniazid-resistant (MDR-TB).This study underscores the need for comprehensive TB control strategies, especially regarding co-infection with HIV and the emergence of drug-resistant strains, emphasizing the importance of early detection and tailored management in Southern Italy.http://www.sciencedirect.com/science/article/pii/S2405579425000038MigrationRifampicinMDRTB/HIVEpidemiologyPublic health |
| spellingShingle | Salvatore Rotundo Salvatore Nisticò Helen Linda Morrone Luigia Gallo Saveria Dodaro Carmelo Papola Pasquale Minchella Giovanni Matera Francesca Greco Luigi Principe Lorenzo Antonio Surace Francesco Lucia Francesca Serapide Alessandro Russo Carlo Torti Enrico Maria Trecarichi Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Migration Rifampicin MDR TB/HIV Epidemiology Public health |
| title | Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study |
| title_full | Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study |
| title_fullStr | Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study |
| title_full_unstemmed | Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study |
| title_short | Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study |
| title_sort | tuberculosis and drug resistance in a region of southern italy among native and foreign born populations a twelve year province based study |
| topic | Migration Rifampicin MDR TB/HIV Epidemiology Public health |
| url | http://www.sciencedirect.com/science/article/pii/S2405579425000038 |
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