Effects of tributyltin on placental and reproductive abnormalities in offspring
ABSTRACT Tributyltin (TBT) is an organotin compound and a common persistent environmental pollutant with endocrine-disrupting chemical (EDC) actions. It can accumulate in the environment at various concentrations throughout the food chain in the ecosystem, posing a risk to human health, especially d...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Brazilian Society of Endocrinology and Metabolism
2025-01-01
|
| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000703&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592460291768320 |
|---|---|
| author | Charles S. da Costa Hanin Alahmadi Genoa R. Warner Maria Tereza Nunes Glaecir Roseni Mundstock Dias Leandro Miranda-Alves Jones B. Graceli |
| author_facet | Charles S. da Costa Hanin Alahmadi Genoa R. Warner Maria Tereza Nunes Glaecir Roseni Mundstock Dias Leandro Miranda-Alves Jones B. Graceli |
| author_sort | Charles S. da Costa |
| collection | DOAJ |
| description | ABSTRACT Tributyltin (TBT) is an organotin compound and a common persistent environmental pollutant with endocrine-disrupting chemical (EDC) actions. It can accumulate in the environment at various concentrations throughout the food chain in the ecosystem, posing a risk to human health, especially during critical periods such as gestation and fetal and offspring development. In this review, we report the results of studies describing the consequences of TBT exposure on placental and reproductive parameters in offspring of both sexes. Results from in vivo and in vitro studies clearly indicate that TBT causes adverse effects on placental development and reproductive parameters in offspring. However, substantial knowledge gaps remain in the literature, requiring further research to better understand the mechanisms behind TBT effects on placental and reproductive disruption in offspring. |
| format | Article |
| id | doaj-art-8eb17416b3764f3d83c5d0f70882f143 |
| institution | Kabale University |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-8eb17416b3764f3d83c5d0f70882f1432025-01-21T07:45:36ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-01-0168spe110.20945/2359-4292-2024-0186Effects of tributyltin on placental and reproductive abnormalities in offspringCharles S. da Costahttps://orcid.org/0000-0003-3616-8211Hanin Alahmadihttps://orcid.org/0009-0007-8047-2524Genoa R. Warnerhttps://orcid.org/0000-0001-8382-1522Maria Tereza Nuneshttps://orcid.org/0000-0003-3375-4020Glaecir Roseni Mundstock Diashttps://orcid.org/0000-0002-6054-8698Leandro Miranda-Alveshttps://orcid.org/0000-0001-7832-8717Jones B. Gracelihttps://orcid.org/0000-0001-9349-4369ABSTRACT Tributyltin (TBT) is an organotin compound and a common persistent environmental pollutant with endocrine-disrupting chemical (EDC) actions. It can accumulate in the environment at various concentrations throughout the food chain in the ecosystem, posing a risk to human health, especially during critical periods such as gestation and fetal and offspring development. In this review, we report the results of studies describing the consequences of TBT exposure on placental and reproductive parameters in offspring of both sexes. Results from in vivo and in vitro studies clearly indicate that TBT causes adverse effects on placental development and reproductive parameters in offspring. However, substantial knowledge gaps remain in the literature, requiring further research to better understand the mechanisms behind TBT effects on placental and reproductive disruption in offspring.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000703&lng=en&tlng=enTributyltintoxicityplacentaoffspringovarytestes |
| spellingShingle | Charles S. da Costa Hanin Alahmadi Genoa R. Warner Maria Tereza Nunes Glaecir Roseni Mundstock Dias Leandro Miranda-Alves Jones B. Graceli Effects of tributyltin on placental and reproductive abnormalities in offspring Archives of Endocrinology and Metabolism Tributyltin toxicity placenta offspring ovary testes |
| title | Effects of tributyltin on placental and reproductive abnormalities in offspring |
| title_full | Effects of tributyltin on placental and reproductive abnormalities in offspring |
| title_fullStr | Effects of tributyltin on placental and reproductive abnormalities in offspring |
| title_full_unstemmed | Effects of tributyltin on placental and reproductive abnormalities in offspring |
| title_short | Effects of tributyltin on placental and reproductive abnormalities in offspring |
| title_sort | effects of tributyltin on placental and reproductive abnormalities in offspring |
| topic | Tributyltin toxicity placenta offspring ovary testes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000703&lng=en&tlng=en |
| work_keys_str_mv | AT charlessdacosta effectsoftributyltinonplacentalandreproductiveabnormalitiesinoffspring AT haninalahmadi effectsoftributyltinonplacentalandreproductiveabnormalitiesinoffspring AT genoarwarner effectsoftributyltinonplacentalandreproductiveabnormalitiesinoffspring AT mariaterezanunes effectsoftributyltinonplacentalandreproductiveabnormalitiesinoffspring AT glaecirrosenimundstockdias effectsoftributyltinonplacentalandreproductiveabnormalitiesinoffspring AT leandromirandaalves effectsoftributyltinonplacentalandreproductiveabnormalitiesinoffspring AT jonesbgraceli effectsoftributyltinonplacentalandreproductiveabnormalitiesinoffspring |