BMDM-derived ORP8 suppresses lipotoxicity and inflammation by relieving endoplasmic reticulum stress in mice with MASH

BMDM-derived ORP8 suppresses lipotoxicity and inflammation by relieving endoplasmic reticulum stress in mice with MASH

Abstract Background and aims Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases worldwide, and specific treatment modalities are lacking. Accumulating evidence suggests that hepatic inflammation plays a key role in the progression from hepatic st...

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Bibliographic Details
Main Authors: Yi Chen, Kangjie Xie, Caiyang Chen, Xihui Wang, Chenchen Ma, Zhangxiang Huang, Yingfu Jiao, Weifeng Yu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Bone marrow-derived macrophages
Endoplasmic reticulum stress
Extracellular vesicles
Lipotoxicity
Metabolic dysfunction-associated steatohepatitis
Online Access:https://doi.org/10.1186/s10020-025-01275-6
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https://doi.org/10.1186/s10020-025-01275-6

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