Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies
The tumor microenvironment has recently been well-studied in various gastrointestinal cancers, including colorectal cancer (CRC). The gut microbiota, a collection of microorganisms in the human gastrointestinal tract, is one of the microenvironments associated with colon carcinogenesis. It has been...
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| Format: | Article |
| Language: | English |
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The Japan Society of Coloproctology
2025-01-01
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| Series: | Journal of the Anus, Rectum and Colon |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-080/_pdf/-char/en |
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| _version_ | 1832584941541523456 |
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| author | Hiroyuki Takamaru Cynthia Tsay Satoshi Shiba Shinichi Yachida Yutaka Saito |
| author_facet | Hiroyuki Takamaru Cynthia Tsay Satoshi Shiba Shinichi Yachida Yutaka Saito |
| author_sort | Hiroyuki Takamaru |
| collection | DOAJ |
| description | The tumor microenvironment has recently been well-studied in various gastrointestinal cancers, including colorectal cancer (CRC). The gut microbiota, a collection of microorganisms in the human gastrointestinal tract, is one of the microenvironments associated with colon carcinogenesis. It has been challenging to elucidate the mechanisms by which gut microbiota contributes to carcinogenesis and cancer progression due to complex interactions with the host, including its metabolites and immune and inflammatory responses. Various studies described the influence of diet on reported changes in the composition and microbiota of gut bacteria and its association with CRC. In recent years, metagenomic techniques such as shotgun sequencing and genome-wide association studies focused on understanding the role of the microbiota and the metabolome on early CRCs and colon carcinogenesis to determine if there are modifiable or intervenable targets for CRC. In this review, we will attempt to provide an overview of gut microbiota related to CRC, with particular attention to the findings of recent studies. |
| format | Article |
| id | doaj-art-8e80bf1836c04cb981f6ec1df2170c09 |
| institution | Kabale University |
| issn | 2432-3853 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Japan Society of Coloproctology |
| record_format | Article |
| series | Journal of the Anus, Rectum and Colon |
| spelling | doaj-art-8e80bf1836c04cb981f6ec1df2170c092025-01-27T10:02:40ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532025-01-0191202410.23922/jarc.2024-0802024-080Microbiome and Colorectal Cancer in Humans: A Review of Recent StudiesHiroyuki Takamaru0Cynthia Tsay1Satoshi Shiba2Shinichi Yachida3Yutaka Saito4Endoscopy Division, National Cancer Center HospitalDivision of Gastroenterology and Hepatology, Weill Cornell Medical CollegeDivision of Cancer Genomics, National Cancer Center Research InstituteDepartment of Cancer Genome Informatics, Graduate School of Medicine, Osaka UniversityEndoscopy Division, National Cancer Center HospitalThe tumor microenvironment has recently been well-studied in various gastrointestinal cancers, including colorectal cancer (CRC). The gut microbiota, a collection of microorganisms in the human gastrointestinal tract, is one of the microenvironments associated with colon carcinogenesis. It has been challenging to elucidate the mechanisms by which gut microbiota contributes to carcinogenesis and cancer progression due to complex interactions with the host, including its metabolites and immune and inflammatory responses. Various studies described the influence of diet on reported changes in the composition and microbiota of gut bacteria and its association with CRC. In recent years, metagenomic techniques such as shotgun sequencing and genome-wide association studies focused on understanding the role of the microbiota and the metabolome on early CRCs and colon carcinogenesis to determine if there are modifiable or intervenable targets for CRC. In this review, we will attempt to provide an overview of gut microbiota related to CRC, with particular attention to the findings of recent studies.https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-080/_pdf/-char/enmicrobiotametabolomecolorectal cancermetagenomic analysis |
| spellingShingle | Hiroyuki Takamaru Cynthia Tsay Satoshi Shiba Shinichi Yachida Yutaka Saito Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies Journal of the Anus, Rectum and Colon microbiota metabolome colorectal cancer metagenomic analysis |
| title | Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies |
| title_full | Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies |
| title_fullStr | Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies |
| title_full_unstemmed | Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies |
| title_short | Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies |
| title_sort | microbiome and colorectal cancer in humans a review of recent studies |
| topic | microbiota metabolome colorectal cancer metagenomic analysis |
| url | https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-080/_pdf/-char/en |
| work_keys_str_mv | AT hiroyukitakamaru microbiomeandcolorectalcancerinhumansareviewofrecentstudies AT cynthiatsay microbiomeandcolorectalcancerinhumansareviewofrecentstudies AT satoshishiba microbiomeandcolorectalcancerinhumansareviewofrecentstudies AT shinichiyachida microbiomeandcolorectalcancerinhumansareviewofrecentstudies AT yutakasaito microbiomeandcolorectalcancerinhumansareviewofrecentstudies |