Refining centromedian nucleus stimulation for generalized epilepsy with targeting and mechanistic insights from intraoperative electrophysiology

Abstract Epilepsy affects 65 million people worldwide, with 30% suffering from drug-resistant epilepsy. While surgical resection is the primary treatment, its application is limited in generalized epilepsy. Centromedian nucleus neurostimulation offers a promising alternative, yet its mechanisms rema...

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Bibliographic Details
Main Authors: Jonathan C. Ho, Thandar Aung, Arianna Damiani, Lilly Tang, Arka N. Mallela, Donald J. Crammond, Jorge A. González-Martínez
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60183-9
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