Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): statistical analysis plan for a randomised controlled trial

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): statistical analysis plan for a randomised controlled trial

Abstract Background Atrial fibrillation causes one-fifth of ischaemic strokes, with a high risk of early recurrence. Although long-term anticoagulation is highly effective for stroke prevention in atrial fibrillation, initiation after stroke can be delayed by concerns over intracranial haemorrhage r...

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Main Authors: Norin Ahmed, Hakim-Moulay Dehbi, Nick Freemantle, Jonathan Best, Philip S. Nash, James K. Ruffle, David Doig, David J. Werring
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Trials
Subjects:
Statistical analysis plan
Atrial fibrillation
Acute ischaemic stroke
Anticoagulation
DOAC (direct oral anticoagulants)
Timing
Online Access:https://doi.org/10.1186/s13063-025-08761-6
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https://doi.org/10.1186/s13063-025-08761-6

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