Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetesResearch in context

Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetesResearch in context

Summary: Background: Type 1 diabetes (T1D) is an autoimmune disease that causes destruction of the insulin-producing pancreatic beta cell, resulting in high levels of blood glucose and profound alterations in carbohydrate, lipid, and protein metabolism if untreated. We aimed to identify if circulat...

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Bibliographic Details
Main Authors: Basile Jumentier, Isabel Gamache, Dominika A. Michalek, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S. Rich, Constantin Polychronakos, Despoina Manousaki
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EBioMedicine
Subjects:
Diabetes type 1
Metabolites
Mendelian randomisation
Biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002518
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