Histones in neutrophil extracellular traps (NETs) contain oxidative post-translational modifications induced by the myeloperoxidase oxidant hypochlorous acid

Histones in neutrophil extracellular traps (NETs) contain oxidative post-translational modifications induced by the myeloperoxidase oxidant hypochlorous acid

Extracellular traps (NETs) released by neutrophils during inflammation play a role in clearing infection but also contribute to disease pathology. NETs consist of a DNA backbone containing histones, anti-microbial granule proteins, such as myeloperoxidase (MPO), and other proteins. MPO remains enzym...

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Bibliographic Details
Main Authors: Helen Hemmling, Line A.E. Hallberg, Per Hägglund, Clare L. Hawkins
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Redox Biology
Subjects:
Neutrophil
Hypochlorous acid
Post-translational modification
3-Chlorotyrosine
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002095
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