Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments
Introduction and objective: Acne vulgaris is a common chronic inflammatory skin disease affecting hair and sebaceous follicles, characterized by skin lesions most commonly appearing on the face. Several factors predispose individuals to the development of acne, including hormonal imbalances, geneti...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-02-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57570 |
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| author | Krzysztof Dobrzeniecki Anna Zygmunt Karolina Karoń Łukasz Karoń Patrycja Karnas-Bogacka |
| author_facet | Krzysztof Dobrzeniecki Anna Zygmunt Karolina Karoń Łukasz Karoń Patrycja Karnas-Bogacka |
| author_sort | Krzysztof Dobrzeniecki |
| collection | DOAJ |
| description |
Introduction and objective: Acne vulgaris is a common chronic inflammatory skin disease affecting hair and sebaceous follicles, characterized by skin lesions most commonly appearing on the face. Several factors predispose individuals to the development of acne, including hormonal imbalances, genetic predisposition, and the use of certain medications. This review aims to evaluate and summarize first-line and advanced pharmacological treatments for acne vulgaris, highlighting their efficacy, safety, and emerging therapies for optimal management.
Review methods: The literature review utilized databases covering sources from PubMed, Google Scholar, Scopus, and Web of Science using the search terms encompassing the following keywords: ‘acne vulgaris’ and ‘topical retinoid therapy’, ‘benzoyl peroxide’, ‘azelaic acid’, ‘topical antibiotics’, ‘oral antibiotics’, ‘contraceptive agents’, ‘antiandrogen therapy’, ‘isotretinoin’.
Brief description of the state of knowledge: Current treatment methods range from topical therapies (i.e. antibiotics and retinoids) for mild cases to systemic medications (i.e. antibiotics, retinoids, and hormonal) for moderate to severe acne. In most cases, treatment should start with topical therapy.
Summary: Early intervention is crucial to mitigate the risk of scarring and psychosocial consequences. Emerging therapeutic strategies have the potential to enhance treatment outcomes.
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| format | Article |
| id | doaj-art-8dd0cdad7aa94831a65db1796d510de5 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-8dd0cdad7aa94831a65db1796d510de52025-02-06T08:18:20ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-02-017810.12775/JEHS.2025.78.57570Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological TreatmentsKrzysztof Dobrzeniecki0https://orcid.org/0009-0003-2743-2233Anna Zygmunt1https://orcid.org/0009-0002-5849-6347Karolina Karoń2https://orcid.org/0009-0005-0356-8907Łukasz Karoń3https://orcid.org/0009-0009-5083-8307Patrycja Karnas-Bogacka4https://orcid.org/0009-0007-9633-1718University Clinical Hospital of Poznan, Dluga 1/2, 61-848 PoznanDepartment of Pathology and Molecular Diagnostics, Medical University of Silesia in Katowice, Medyków 18, 40-752 KatowiceMunicipal Hospital in Zabrze, Zamkowa 4, 41-803 ZabrzeDepartment of Pathology and Molecular Diagnostics, Medical University of Silesia in Katowice, Medyków 18, 40-752 KatowiceCounty Hospital in Strzyżów, 700-lecia Strzyżowa 1, 38-100 Strzyżów Introduction and objective: Acne vulgaris is a common chronic inflammatory skin disease affecting hair and sebaceous follicles, characterized by skin lesions most commonly appearing on the face. Several factors predispose individuals to the development of acne, including hormonal imbalances, genetic predisposition, and the use of certain medications. This review aims to evaluate and summarize first-line and advanced pharmacological treatments for acne vulgaris, highlighting their efficacy, safety, and emerging therapies for optimal management. Review methods: The literature review utilized databases covering sources from PubMed, Google Scholar, Scopus, and Web of Science using the search terms encompassing the following keywords: ‘acne vulgaris’ and ‘topical retinoid therapy’, ‘benzoyl peroxide’, ‘azelaic acid’, ‘topical antibiotics’, ‘oral antibiotics’, ‘contraceptive agents’, ‘antiandrogen therapy’, ‘isotretinoin’. Brief description of the state of knowledge: Current treatment methods range from topical therapies (i.e. antibiotics and retinoids) for mild cases to systemic medications (i.e. antibiotics, retinoids, and hormonal) for moderate to severe acne. In most cases, treatment should start with topical therapy. Summary: Early intervention is crucial to mitigate the risk of scarring and psychosocial consequences. Emerging therapeutic strategies have the potential to enhance treatment outcomes. https://apcz.umk.pl/JEHS/article/view/57570acne vulgaristopical retinoid therapysystemic antibioticstopical antibioticsisotretinoin |
| spellingShingle | Krzysztof Dobrzeniecki Anna Zygmunt Karolina Karoń Łukasz Karoń Patrycja Karnas-Bogacka Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments Journal of Education, Health and Sport acne vulgaris topical retinoid therapy systemic antibiotics topical antibiotics isotretinoin |
| title | Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments |
| title_full | Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments |
| title_fullStr | Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments |
| title_full_unstemmed | Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments |
| title_short | Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments |
| title_sort | acne vulgaris management a review of first line and advanced pharmacological treatments |
| topic | acne vulgaris topical retinoid therapy systemic antibiotics topical antibiotics isotretinoin |
| url | https://apcz.umk.pl/JEHS/article/view/57570 |
| work_keys_str_mv | AT krzysztofdobrzeniecki acnevulgarismanagementareviewoffirstlineandadvancedpharmacologicaltreatments AT annazygmunt acnevulgarismanagementareviewoffirstlineandadvancedpharmacologicaltreatments AT karolinakaron acnevulgarismanagementareviewoffirstlineandadvancedpharmacologicaltreatments AT łukaszkaron acnevulgarismanagementareviewoffirstlineandadvancedpharmacologicaltreatments AT patrycjakarnasbogacka acnevulgarismanagementareviewoffirstlineandadvancedpharmacologicaltreatments |